IgG抗-AB对血型抗体效价与胎儿新生儿溶血病患儿血清总胆红素相关性分析的影响  

Effect of IgG anti AB antibody on the correlation analysis between the titer of blood group antibodies and total bilirubin in serum of newborns with hemolytic disease

作　　者：张怡 程晨 陈怡静 骆群 卓海龙 ZHANG Yi;CHENG Chen;CHEN Yijing;LUO Qun;ZHUO Hailong(The Fifth Medical Center of PLA General Hospital,Beijing 100071,China)

机构地区：[1]解放军总医院第五医学中心,北京100071

出　　处：《中国输血杂志》2023年第11期1004-1008,共5页Chinese Journal of Blood Transfusion

基　　金：北京市科技计划项目(Z181100001718213)。

摘　　要：目的探讨ABO胎儿新生儿溶血病(ABO hemolytic disease of the fetus and newborn,ABO-HDFN)患儿O型母亲血清经IgG抗-AB吸收前后抗-A或抗-B效价水平与患儿血清总胆红素的相关性。方法选取2020年1—12月送检北京市血液中心119名确诊为ABO-HDFN的患儿及母亲血清标本,并收集患儿的临床资料。对患儿进行溶血三项试验、血清总胆红素(TBIL)测定,母亲血清经IgG抗-AB吸收前后进行IgG抗-A或抗-B效价检测,对IgG抗体效价水平及患儿TBIL结果进行统计学分析,并比较IgG抗体不同效价水平对应的TBIL结果差异,用Spearman检验分析吸收IgG抗-AB前后IgG抗-A或抗-B效价与TBIL结果的相关性。结果O型母亲血清经IgG抗-AB吸收后IgG抗-A或抗-B效价在各水平上时所对应的TBIL结果存在差异(F=8.401、19.622,P均<0.05);母亲血清经IgG抗-AB吸收前IgG抗-A或抗-B效价与新生儿TBIL结果无显著相关性(r=0.181、0.248,P>0.05);母亲血清经IgG抗-AB吸收后IgG抗-A或抗-B效价与新生儿TBIL结果呈正相关(r=0.487、0.629,P均<0.05)。结论O型母亲血清经IgG抗-AB吸收后IgG抗-A或抗-B效价与ABO-HDFN患儿TBIL结果呈正相关,通过检测经IgG抗-AB吸收后母亲血清IgG抗-A或抗-B效价水平可以准确地预测新生儿血清总胆红素升高趋势。Objective To investigate the correlation between the titer of anti-A or anti-B antibodies before and after the absorption of IgG anti-AB antibodies in the serum of type O mothers with ABO hemolytic disease of fetus and newborn(ABO-HDFN)and the total bilirubin in the serum of the children.Methods Serum samples from 119 children diagnosed with ABO-HDFN and their mothers sent to the Beijing Red Cross Blood Center from January to December 2020 were selected,and clinical data of the children were collected.Three hemolysis tests and serum total bilirubin(TBIL)determination were con-ducted on the children.IgG anti-A or anti-B antibody titers were tested before and after the mother's serum absorbed IgG anti-AB antibodies.Statistical analysis was conducted on the IgG antibody titers and the TBIL results of the children.The differences in TBIL results corresponding to different IgG antibody titers were compared.The Spearman test was used to analyze the correlation between the IgG anti-A or-B antibody titers and TBIL results before and after the absorption of IgG anti-AB anti-bodies.Results There were differences in the TBIL results corresponding to IgG anti-A or anti-B titers at different levels in the serum of type O mothers after absorption by IgG anti-AB antibodies(F=8.401,19.622,P<0.05).There was no significant correlation between the IgG anti-A or anti-B titers of maternal serum before absorption by IgG anti-AB antibodies and neonatal TBIL results(r=0.181,0.248,P>0.05).The IgG anti-A or anti-B titers of maternal serum absorbed by IgG anti-AB antibodies were positively correlated with neonatal TBIL results(r=0.487,0.629,P<0.05).Conclusion There is a positive correlation between the titer of IgG anti-A or anti-B antibodies in the serum of type O mothers after absorbing IgG anti-AB antibodies and the TBIL results of ABO-HDFN children.The trend of increased total bilirubin in newborn serum ban be accurately predicted by detecting the titer level of IgG anti-A or anti-B antibodies in the serum of mothers after absorbing Ig

关 键 词：IgG抗-AB ABO血型不合 胎儿新生儿溶血病 高胆红素血症 

分 类 号：R556.63[医药卫生—血液循环系统疾病]