去白细胞混合浓缩血小板制备的质量控制及临床应用效果观察  

Preparation quality control and clinical application observation of pooled platelets with leukocytes reduced

作　　者：郭敏[1] 李建民[1] 刘建辉[2] 杨宁 张静[1] 李玉秋[1] 程菲[1] 刘旭枝[1] 贺强 和苗 杨文娟[1] GUO Min;LI Jianmin;LIU Jianhui;YANG Ning;ZHANG Jing;LI Yuqiu;CHENG Fei;LIU Xuzhi;HE Qiang;HE Miao;YANG Wenjuan(Hebei Province Blood Center,Shijiazhang 050071,China;Department of Blood Transfusion,Hebei Provincial People's Hospital)

机构地区：[1]河北省血液中心,河北石家庄050071 [2]河北省人民医院输血科

出　　处：《中国输血杂志》2023年第11期1025-1028,共4页Chinese Journal of Blood Transfusion

基　　金：河北省医学科学研究课题计划指令性课题(20231233)。

摘　　要：目的对去白细胞混合浓缩血小板制备质量及临床应用效果进行调查。方法将白膜法制备的去白细胞混合浓缩血小板实验组(40例)的质量及临床应用效果与去白细胞单采血小板对照组(40例)的质量及临床应用效果进行对比。结果经检测实验组和对照组的血小板容量(mL)、血小板计数(×10^(11))、红细胞混入量(×10^(8))和白细胞残留量(×10^(6))分别为278.90±7.92 vs 276.52±8.01、2.66±0.09 vs 2.66±0.83、0.54±0.42 vs 0.83±0.84、0.29±0.54 vs 0.27±0.51,二者之间表现并无显著差别,且细菌培养结果均为阴性,均符合国家相关标准要求;另在临床应用效果评价指标CCI(×10^(3),24h)和PPR(%)上分别为15.11±9.86 vs 14.61±12.55和54.23±18.70 vs 61.41±19.09,二者之间表现亦无显著差别,可达到一定程度的治疗效果。结论去白细胞混合浓缩血小板质量及临床治疗效果与去白细胞单采血小板质量及临床治疗效果一致。Objective To investigate the preparation quality and clinical application effect of pooled platelets with leuko-cytes reduced.Methods The quality and clinical effect of the buffy-coated method prepared pooled platelets leukocytes reduced(experimental group,n=40)and apheresis platelets leukocytes reduced(control group,n=40)were compared.Results The platelet volume(mL),platelet count(×10^(11)),red blood cell contamination(×10^(8))and residual white blood cell(×10^(6))of the experimental group and control group were 278.90±7.92 vs 276.52±8.01,2.66±0.09 vs 2.66±0.83,0.54±0.42 vs 0.83±0.84,0.29±0.54 vs 0.27±0.51,respectively,with no significant difference.The results of bacterial culture were negative,all met the requirements of relevant national standards.In addition,the CCI(×10^(3),24 h)and PPR(%)were 15.11±9.86 vs 14.61±12.55 and 54.23±18.70 vs 61.41±19.09 respectively,with no significant difference,indicating a certain degree of therapeutic effect.Conclusion The quality and clinical therapeutic effect of pooled platelets leukocytes reduced were consistent with that of apheresis platelets leukocytes reduced.

关 键 词：去白细胞混合浓缩血小板 去白细胞单采血小板 应用效果 

分 类 号：R331.143[医药卫生—人体生理学] R457.14[医药卫生—基础医学]