单采血小板男性献血者血液学指标变化分析  

Analysis of hematological parameters in male plateletpheresis donors

作　　者：陈迎春 钟文娟 陈金英 曾嘉[1] CHEN Yingchun;ZHONG Wenjuan;CHEN Jinying;ZENG Jia(Fujian Blood Center,Fuzhou 350004,China)

机构地区：[1]福建省血液中心,福建福州350004

出　　处：《中国输血杂志》2023年第11期1032-1035,共4页Chinese Journal of Blood Transfusion

摘　　要：目的探讨单采血小板男性献血者血液学指标的变化情况。方法选取本中心194名单采血小板男性献血者,按照献血频次将受试者随机分成两个实验小组,组1(n=107):单采次数≤12次/年;组2(n=87):单采次数>12次/年。分别检测献血者献血前的血清铁蛋白(SF)及相关铁代谢指标;红细胞计数(RBC)、血红蛋白(Hb)、血细胞比容(Hct)、血小板计数(Plt)等血常规指标及网织红细胞计数百分比(RET%)、未成熟网织红细胞比率(IRF)等网织红细胞相关指标,并对这些指标运用统计学方法进行分析。结果与组2比较,组1的RBC、Hb、Hct、SF明显增高,Plt、RET%和IRF明显降低,数据差异有统计学意义(P<0.05);同时组1铁蛋白降低发生的概率更低,数据差异有统计学意义(P<0.05)。结论随着捐献次数的增加,男性献血者更容易发生缺铁,同时骨髓造血功能明显活跃;需关注单采次数>12次/年的单采血小板男性献血者,建议对其进行SF的动态监测,适当延长献血间隔。Objective To investigate the variation of hematological parameters in male plateletpheresis donors.Methods A total of 194 male plateletpheresis donors from Fujian Blood Center were divided into two groups according to the frequen-cy of blood donation:Group 1(n=107),with the number of plateletpheresis donation less than or equal to 12 per year;Group 2(n=87),with the number of plateletpheresis donation more than 12 per year.Serum ferritin(SF)and related iron metabolism indexes,red blood cell count(RBC),hemoglobin(Hb),hematocrit(Hct),platelet count(Plt)and other blood routine indexes,as well as percentage of reticulocyte counts(RET%),immature reticulocyte fraction(IRF)and other reticulocyte indexes were measured before blood donation and analyzed by statistical methods.Results Compared with Group 2,the RBC,Hb,Hct,SF in Group 1 were significantly higher,while Plt,RET% and IRF were significantly lower(P<0.05),and the probability of ferritin decrease in Group 1 was lower,with significant difference(P<0.05).Conclusion As the number of donation increased,male plateletpheresis donors were prone to iron deficiency,and the bone marrow hematopoiesis were obviously enhanced.We should be more concerned about male plateletpheresis donors who donated more than 12 times per year,further more,SF monitoring should be conducted and the blood donation interval should be appropriately extended.

关 键 词：单采献血者 铁代谢 网织红细胞参数 

分 类 号：R331.143[医药卫生—人体生理学] R446.11[医药卫生—基础医学] R193.3