中药质量评价研究现状及“质-量”双标评价方法探讨  

Research status of quality evaluation of traditional Chinese medicine and discussion on“quality-quantity”double standard evaluation method

作　　者：孟宪生[1,2,3] 罗曦 贾梦楠 包永睿 王帅[1,2,3] 李天娇 MENG Xian-sheng;LUO Xi;JIA Meng-nan;BAO Yong-rui;WANG Shuai;LI Tian-jiao(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China;Liaoning Multi-dimensional Analysis of Traditional Chinese Medicine Technical Innovation Center,Dalian 116600,China;Liaoning Province Modern Traditional Chinese Medicine Research and Engineering Laboratory,Dalian 116600,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁省中药多维分析专业技术创新中心,辽宁大连116600 [3]辽宁省现代中药研究工程实验室,辽宁大连116600

出　　处：《中草药》2023年第22期7281-7286,共6页Chinese Traditional and Herbal Drugs

基　　金：辽宁省教育厅创新团队项目(LT2017015)。

摘　　要：中药品种来源宽泛、化学成分复杂,导致中药质量良莠不齐。完善中药质量评价标准,一直被认为是制约我国传统中医药现代化发展的重点、难点问题。针对我国目前中药质量评价研究现状,总结了中药质量评价的关键科学问题,并提出了中药“质-量”双标评价方法。以对照药材为基准物质建立特征图谱,开展基于对照药材的定性研究;以保留时间稳定且价格低廉、易获得的内标物质作为定量评价指标,开展基于内标物质的药效成分相对定量研究。该方法旨在科学、明晰地辨别中药的真伪优劣,降低企业生产的经济负担和广大民众的用药成本,切实保障中药质量。The variety source of traditional Chinese medicine(TCM)is wide and the chemical composition is complex,leading to the quality of TCM is uneven.Improving the quality evaluation criteria of TCM has always been regarded as an important and difficult problem restricting the modernization of TCM.According to the current research status of the quality evaluation of TCM,the key scientific problems of the quality evaluation of TCM were summarized,and the“quality-quantity”double standard evaluation method of TCM was put forward.The contrast medicinal materials were used as standard substances to establish the characteristic chromatogram,and the qualitative research was carried out based on the contrast medicinal materials.Taking internal standard substances with stable retention time and low price and easy access as quantitative evaluation index,the relative quantitative research on the efficacy components based on internal standard substances was carried out in order to scientifically and clearly identify the authenticity of TCM,reduce the economic burden of production and drug costs of the public,and effectively guarantee the quality of TCM.

关 键 词：中药 “质-量”双标 对照药材 质量评价 特征图谱 药效成分 

分 类 号：R286.02[医药卫生—中药学]