大黄防治肝病的研究进展  

Research progress on Rhei Radix et Rhizoma in prevention and treatment of liver diseases

作　　者：杨天文 周纪军 廖玉 吕文良[2] YANG Tian-wen;ZHOU Ji-jun;LIAO Yu;LYU Wen-liang(The First Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Infectious Diseases,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712046 [2]中国中医科学院广安门医院感染疾病科,北京100053

出　　处：《中草药》2023年第22期7536-7544,共9页Chinese Traditional and Herbal Drugs

基　　金：中国中医科学院科技创新工程(C12021A00801)。

摘　　要：随着生活水平提高、压力增大,越来越多的人存在饮食不节、情志失调等亚健康状态,肝脏疾病的发病率逐年上升,寻找安全有效的治疗药物是目前研究热点。大黄味苦性寒,具有荡涤肠胃、推陈致新、通利水谷、调中化食、安和五脏的功效,在临床上应用广泛,与清热利湿药配伍可以治疗湿热蕴结所致的慢性乙型病毒性肝炎、酒精性肝损伤;与消食导滞药配伍可以治疗膏浊内蕴积热所致的非酒精性脂肪肝;与活血消癥药配伍可以治疗瘀血阻络所致的肝纤维化、肝癌;与逐水消肿药配伍可以治疗湿邪内停所致的肝硬化腹水等。通过总结近年来研究,发现大黄活性成分可通过多机制、多靶点防治肝脏疾病,具有良好的发展潜力,为后续研究和临床应用提供思路。With the improvement of living standards and the increase of pressure,more and more people have sub-health conditions such as irregular diet and emotional disorders,and the incidence of liver diseases is increasing year by year.The search for safe and effective therapeutic drugs is currently a research hotspot.Dahuang(Rhei Radix et Rhizoma),a traditional Chinese medicine,which is bitter in taste and cold in nature,has the effects of cleaning the intestines and stomach,promoting metabolism,dredging and smoothing the intestines to benefit digestion,regulating the middle energizer and digesting food,and harmonizing the five zang-organs.It is widely used in clinic,and can treat chronic hepatitis B and alcoholic liver injury caused by dampness-heat accumulation in combination with heat-clearing drugs.Combination with anti-food retardation drugs can treat nonalcoholic fatty liver disease caused by Sputum-heat accumulation.Combination with blood circulation and stasis removal drugs can treat liver fibrosis and liver cancer caused by blood stasis.Combined with diuretics and hydragogues drugs can treat liver cirrhosis and ascites caused by dampness originating from interior.Through summarizing recent studies,it is found that Rhei Radix et Rhizoma active ingredients can prevent and treat liver diseases through multi-mechanism and multi-target,which has good development potential,offering suggestions for subsequent research and clinical application.

关 键 词：大黄 游离蒽醌 肝病 信号通路 临床经验 大黄酸 大黄素 大黄酚 芦荟大黄素 大黄素甲醚 

分 类 号：R285[医药卫生—中药学]