人参皂苷Rg_(3)抗肿瘤纳米给药系统研究进展  

Research progress on antitumor nanoscale drug delivery system of ginsenoside Rg_(3)

作　　者：刘晓瑞 张坤峰 李鑫[1] 王向涛 LIU Xiao-rui;ZHANG Kun-feng;LI Xin;WANG Xiang-tao(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中草药》2023年第22期7577-7587,共11页Chinese Traditional and Herbal Drugs

基　　金：中国医学科学院医学与健康创新工程项目资助(2021-I2M-1-071);黑龙江省重点研发计划指导类项目(GZ20210092)。

摘　　要：人参皂苷Rg_(3)(ginsenoside Rg_(3),Rg_(3))是人参中主要的活性成分之一,具有广泛的药理活性,尤其在抗肿瘤研究方面备受关注。然而,Rg_(3)在水中溶解度差和生物利用度低等问题极大地限制了Rg_(3)的临床应用。纳米给药系统在改善Rg_(3)水溶性差、延缓Rg_(3)体内代谢等方面取得了一定的进展,并已开发出具有不同诊疗功能的Rg_(3)纳米药物,显著提高了Rg_(3)的抗癌效果。通过对近年来Rg_(3)纳米药物及其在抗肿瘤方面的研究进行综述,为Rg_(3)的进一步研究提供参考。Ginsenoside Rg_(3)(Rg_(3))is one of the main active ingredients in ginseng and has a wide range of pharmacological activities,especially in the field of antitumor.However,the poor solubility and low bioavailability of Rg_(3) in water have greatly limited the clinical application of Rg_(3).Nano drug delivery systems have made progress in improving the poor water solubility of Rg_(3) and delaying the metabolism of Rg_(3) in vivo,and have developed Rg_(3) nanodrugs with different therapeutic functions,which have significantly improved the anti-cancer effect of Rg_(3).In this paper,the recent research of Rg_(3) nanomedicine and its application in antitumor was reviewed to provide a reference for further research on Rg_(3).

关 键 词：人参皂苷Rg_(3) 抗肿瘤 纳米给药系统 生物利用度 纳米医学 

分 类 号：R283[医药卫生—中药学]