尿C肽/肌酐评估1型糖尿病残存胰岛功能及并发症风险的应用价值  

The value of urinary C⁃P/creatinine in assessing residual islet function and risk of complications in type 1 diabetes mellitus

作　　者：乔程程 沈山梅[1] 凌清 瞿朵朵 张溦 毕艳[1] 陆婧[1] QIAO Chengcheng;SHEN Shanmei;LING Qing(Department of Endocrinology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210000,China)

机构地区：[1]南京大学医学院附属鼓楼医院内分泌科,210000

出　　处：《中国糖尿病杂志》2023年第10期759-763,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金(82270887);南京市卫生科技发展专项资金项目(YKK21080);南京鼓楼医院临床研究专项资金项目培育项目(2021-LCYJ-PY-10)。

摘　　要：目的探讨尿C-P/肌酐(UCPCR)评估T1DM残存胰岛功能及并发症风险的应用价值。方法选取2019年1月至2020年1月于南京鼓楼医院内分泌科就诊的T1DM患者75例,以UCPCR 0.2 pmol/μmol为切点值,将T1DM患者分为有胰岛功能组19例(PF,UCPCR≥0.2 pmol/μmol)、微量胰岛功能组42例(MF,0<UCPCR<0.2 pmol/μmol)及无胰岛功能组14例(LF,UCPCR=0 pmol/μmol)。结果Pearson相关分析显示,UCPCR与FC-P、2 hC-P呈正相关(P<0.05),UCPCR<0.2 pmol/μmol时胰岛功能绝对缺乏。Spearman相关分析显示,UCPCR与DR患病率、心血管病(CVD)风险呈负相关(P<0.05),UCPCR<0.02 pmol/μmol时存在高危或极高危CVD风险。结论UCPCR是反应T1DM残存胰岛功能的敏感指标,对评估DR及CVD风险有应用价值。Objective To explore the application value of urinary C-P/creatinine(UCPCR)in evaluating residual pancreatic islet function and the risk of complications in type 1 diabetes mellitus(T1DM)patients.Methods 75 T1DM patients who visited the Endocrinology Department of Nanjing Drum Tower Hospital from January 2019 to January 2020 were selected.Using UCPCR 0.2 pmol/μmol as the cutoff point,T1DM patients were divided into 19 patients with pancreatic function(PF,UCPCR≥0.2 pmol/μmol),42 patients with minimal pancreatic function(MF,0<UCPCR<0.2 pmol/μmol),and 14 patients without pancreatic function(LF,UCPCR=0 pmol/μmol).Results Pearson correlation analysis showed that UCPCR was positively correlated with FC-P and 2 hC-P(P<0.05).When UCPCR was less than 0.2 pmol/μmol,pancreatic islet function was absolutely lacking.Spearman correlation analysis showed that UCPCR was negatively correlated with the incidence of DR and the risk grading of cardiovascular disease(CVD)(P<0.05).When UCPCR<0.02 pmol/μmol,there was a high or extremely high risk of CVD.Conclusion 24-hour UCPCR is a sensitive indicator of residual pancreatic islet function and has potential application value in assessing the risk of diabetic retinopathy and cardiovascular disease in patients with T1DM.

关 键 词：尿C-P/肌酐 糖尿病 1型 残余胰岛功能 糖尿病并发症 

分 类 号：R587.2[医药卫生—内分泌]