各组织来源外泌体参与胰岛功能调控的研究进展  

Research progress of tissue-derived exosomes involved in the regulation of islet function

作　　者：魏宇 唐元静 阮玉婷[2] WEI Yu;TANG Yuanjing;RUAN Yuting(The Second Clinical School of Medicine,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学第二临床医学院,广州510515 [2]南方医科大学珠江医院内分泌代谢科

出　　处：《中国糖尿病杂志》2023年第11期865-868,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(82100860);广东省自然科学基金(2019A1515110658)。

摘　　要：DM患病率逐年升高,寻找更好的诊治方法非常重要。外泌体是细胞分泌的一种微小囊泡,承担细胞间信号沟通媒介的作用。近年来,有关外泌体影响胰岛凋亡、再生和免疫反应等病理生理过程的研究取得进展。本文综述各组织来源外泌体参与胰岛功能调控的研究进展。With an increasing prevalence of diabetes mellitus,it is important to find better diagnosis and treatment methods.Exosomes are tiny vesicles secreted by cells and act as mediators of signal communication between cells.In recent years,many achievements have been made in the study of the effects of exosomes on islet apoptosis,regeneration,immune response and other pathophysiological processes.This article reviews the research progress of exosomes from different tissue sources in the regulation of islet function.

关 键 词：外泌体 糖尿病 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]