肺纤维化血清生物标志物的研究进展  

Research Progress in Serum Biomarkers of Pulmonary Fibrosis

作　　者：张飞宇 孙梦迪 杨慧聪 卢芳[2] 于栋华[2] 陈平平[2] 王宇[2] 刘树民[2] ZHANG Feiyu;SUN Mengdi;YANG Huicong;LU Fang;YU Donghua;CHEN Pingping;WANG Yu;LIU Shumin(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学中医药研究院,哈尔滨150040

出　　处：《医学综述》2023年第22期4856-4860,4866,共6页Medical Recapitulate

基　　金：黑龙江中医药大学优秀创新人才(领军人才)项目(2018RCL13)。

摘　　要：检测血液中的生物标志物是诊断疾病的重要方法。肺纤维化的发生可能会引起血液中相关物质含量变化或肺组织中的物质通过气-血屏障进入血液。目前与肺纤维化密切相关的血清生物标志物包括涎液化糖链抗原、转化生长因子-β_(1)、基质金属蛋白酶7、表面活性蛋白、克拉拉细胞蛋白16、趋化因子、血小板衍生生长因子和高迁移率族蛋白。通过检测血液中的这些标志物综合判断是确定肺纤维化程度的理想方法,且具有可量化、可动态监测的优势,确定多种因子的联合检测已成为肺纤维化诊断的研究方向。Detecting biomarkers in blood is an important method for diagnosing diseases.The occurrence of pulmonary fibrosis may cause changes in the content of related substances in the blood or substances in lung tissue entering the blood through the air-blood barrier.Currently,serum biomarkers closely related to pulmonary fibrosis in research include krebs von den lungen,transforming growth factors-β_(1),matrix metalloproteinase-7,surface active protein,Clara cell protein 16,chemokines,platelet-derived growth factor,and high mobility group proteins.The comprehensive determination of these biomarkers in the blood through detection is an ideal method for determining the degree of pulmonary fibrosis,which has the advantages of being quantifiable and dynamically monitored.Identifying the combination of multiple factors has become a research direction in the diagnosis of pulmonary fibrosis.

关 键 词：肺纤维化 血清生物标志物 涎液化糖链抗原 转化生长因子-β_(1) 基质金属蛋白酶 

分 类 号：R563[医药卫生—呼吸系统]