补肾活血药治疗股骨头坏死的研究进展  

Research Progress in Treatment of Osteonecrosis of Femoral Head with Kidney Tonics and Blood Activators

作　　者：李培龙 李慧英[2] LI Peilong;LI Huiying(Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Orthopedics and Traumatology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450008,China)

机构地区：[1]河南中医药大学,郑州450000 [2]河南中医药大学第一附属医院骨伤科,郑州450008

出　　处：《医学综述》2023年第22期5068-5072,共5页Medical Recapitulate

基　　金：河南省中医药科学研究专项课题(2021JDZY009,2018ZY2067)。

摘　　要：股骨头坏死为常见的骨科疾病,由多种因素影响导致股骨头局部血运受损,使股骨头结构改变并最终引起股骨头塌陷,其发病机制十分复杂,治疗难度较大,终末期需行髋关节置换手术治疗。中医认为本病以肾精亏虚为本,淤血阻滞为标,属本虚标实之证,治疗当以补肾活血为根本。研究证实多个信号通路如转化生长因子、脂联素/AMP活化的蛋白激酶、Wnt/β联蛋白等共同参与股骨头坏死的发病进程,补肾活血类中药淫羊藿、丹参、三七等单用或复方应用可干预机体相关信号通路,以控制股骨头坏死病程。深入研究其具体机制可为股骨头坏死的治疗提供更多理论依据。Osteonecrosis of the femoral head is a common disease in orthopedics,which is caused by a variety of factors,resulting in damage to the local blood flow of the femoral head,causing structural changes in the femoral head and ultimately leading to the collapse of the femoral head.The pathogenesis is very complex and the treatment is difficult,and the end-stage of the disease needs to be treated with hip joint replacement surgery.According to Chinese medicine,this disease is characterized by deficiency of kidney essence and blockage of blood and sludge,and the treatment should be based on tonifying the kidney and activating the blood.Relalted studies have confirmed that several signaling pathways,such as transforming growth factor,adiponectin/AMP-activated protein kinase,Wnt/β-catenin,etc.,are involved in the pathogenesis of necrosis of the femoral head,and that kidney tonifying and blood-activating herbs such as Epimedium,Salvia divinorum and Panax quinquefolium can intervene in the relevant signaling pathways to control the course of the necrosis of the femoral head.Further study of the specific mechanism can provide more theoretical basis for the treatment.

关 键 词：股骨头坏死 补肾活血 信号通路 

分 类 号：R681[医药卫生—骨科学]