低强度脉冲超声调控治疗疼痛性膝骨关节炎的临床研究  

Clinical study of low intensity pulsed ultrasound in the treatment of painful knee osteoarthritis

作　　者：胡珊珊 刘晓 罗汉才 吴亚运 吴小满 牛丽丽[2] 潘敏 HU Shan-shan;LIU Xiao;LUO Hancai;WU Yayun;WU Xiaoman;NIU Lili;PAN Min(Department of Ultrasound,Shenzhen Hospital of Guangzhou University of Chinese Medicine(Futian),Shenzhen 518034,China;不详)

机构地区：[1]广州中医药大学深圳医院(福田)超声科,广东深圳518034 [2]中国科学院深圳先进技术研究院保罗劳特伯生物医学成像研究中心,广东深圳518055

出　　处：《实用医学杂志》2023年第21期2783-2788,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81971638);深圳市基础研究面上项目(编号:JCYJ20220525213029001,JCYJ20190809105207439);深圳市福田区卫生公益项目(编号:FTWS2022061)。

摘　　要：目的探究低强度脉冲超声调控膝内上、下神经治疗内侧疼痛性膝骨关节炎的临床疗效及安全性。方法收集内侧疼痛性膝骨关节炎患者25例,利用低强度脉冲超声进行治疗,在治疗前、治疗后即刻、治疗后1、2周和4周进行VAS视觉模拟评分、WOMAC和Lysholm膝骨关节炎康复量表评分,比较治疗前与治疗后不同时间段的疗效,并对比治疗前后的超声影像验证其安全性。结果治疗组患者,在治疗前与治疗后即刻、治疗后1周、2周的VAS、WOMAC和Lysholm评分差异有统计学意义(P<0.05),与治疗后4周比较差异无统计学意义(P>0.05)。主要观察指标VAS在治疗前与治疗后即刻、治疗后1、2周相比有显著下降,分别为(5.26±1.12)、(2.76±0.92)、(2.74±1.26)、(3.42±0.93);次要观察指标WOMAC和Lysholm在治疗前、治疗后即刻、治疗后1、2周均有明显的改变,分别为(24.03±4.43)和(66.93±14.14)、(12.75±1.63)和(79.86±10.82)、(12.76±1.82)和(81.93±7.67)、(15.17±2.73)和(77.08±9.73)。治疗前后的超声影像未见明显异常。结论低强度脉冲超声安全有效调控膝周神经治疗疼痛性膝骨关节炎,为临床膝骨关节炎的干预和治疗提供新思路。Objective To explore the clinical efficacy and safety of low-intensity pulse ultrasound in the treatment of medial painful knee osteoarthritis.Methods A total of 10 patients with medial painful knee osteoar‐thritis were collected and treated with low-intensity pulsed ultrasound.VAS visual analogue scores,WOMAC and Lysholm knee osteoarthritis rehabilitation scale scores were performed before treatment,immediately after treatment,1 week,2 weeks and 4 weeks after treatment.The efficacy and safety were compared before and after treatment.The ultrasound images before and after treatment were compared to verify its safety.Result VAS,WOMAC and Lysholm scores were statistically significant before and immediately after treatment,1 week and 2 weeks after treat‐ment(P<0.05),but there was no statistically significant difference between them and 4 weeks after treatment(P>0.05).VAS decreased significantly before treatment,immediately after treatment,1 week after treatment and 2 weeks after treatment,and were(5.26±1.12),(2.76±0.92),(2.74±1.26),(3.42±0.93),respectively.The secondary outcome indicators of WOMAC and Lysholm were significantly changed before treatment,immediately after treatment,1 week after treatment and 2 weeks after treatment.They were(24.03±4.43)and(66.93±14.14),(12.75±1.63)and(79.86±10.82),(12.76±1.82)and(81.93±7.67),(15.17±2.73)and(77.08±9.73),respectively.No significant abnormality was found in the ultrasound images before and after treatment.Conclusion low-intensity pulsed ultrasound safely and effectively regulates the peripheral knee nerve in the treatment of painful knee osteoarthritis,providing a new idea for the intervention and treatment of clinical knee osteoarthritis.

关 键 词：低强度脉冲超声 膝骨关节炎 膝神经 

分 类 号：R454.4[医药卫生—治疗学] R684.3[医药卫生—临床医学]