药物洗脱支架治疗股腘动脉硬化闭塞症的效果分析  

Clinical efficacy of drugeluting stents for femoral popliteal arteriosclerosis obliterans

作　　者：郑浩哲 王兵[1] 牛晓阳[1] 崔文军[1] 王岭 吕正佐 ZHENG Haozhe;WANG Bing;NIU Xiaoyang;CUI Wenjun;WANG Ling;LÜZhengzuo(Department of Vascular Surgery,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院血管外科,郑州450052

出　　处：《实用医学杂志》2023年第21期2796-2801,共6页The Journal of Practical Medicine

基　　金：河南省高等学校重点科研项目(编号:21A320069);河南省医学科技攻关计划(联合共建)项目(编号:LHGJ20190420)。

摘　　要：目的比较药物洗脱支架(drug-eluting stents,DES)与金属裸支架(bare metal stent,BMS)治疗股腘动脉硬化闭塞症的临床疗效。方法回顾性分析郑州大学第五附属医院2020年10月至2021年6月收治的47例股腘动脉硬化闭塞症患者的临床资料,其中24例行药物洗脱支架治疗(DES组),23例行金属裸支架治疗(BMS组),术后对比两组的近中期临床疗效。结果47例患者均顺利完成手术,未发生与手术相关的不良事件。DES组与BMS组相比,术后7 d、3个月两组患者ABI比较差异均无统计学意义,术后6、12、24个月DES组患者ABI增长值均高于BMS组(P<0.05)。术后6个月一期通畅率差异无统计学意义,术后12、24个月一期通畅率分别为(91.7%vs.65.2%、83.3%vs.56.5%,P<0.05)。术后DES组靶病变血运重建率明显低于BMS组有明显的优势(4.0%vs.26.1%,P<0.05)。结论DES治疗股腘动脉硬化闭塞症具有较好的近中期疗效,其临床疗效优于BMS治疗。Objective To investigate the clinical efficacy of drug eluting stents vs metal bare stents for femoral popliteal arteriosclerosis obliterans.Methods The clinical data of 47 patients with femoral popliteal arte⁃riosclerosis obliterans receiving endovascular therapy from October 2020 to June 2021 were retrospectively ana⁃lyzed.A total of 24 cases received drug-eluting stents(DES group)and 23 cases underwent metal bare stents(BMS group).Results All patients successfully completed the operation without any adverse events.There was no statistical difference in ABI between the DES group and the BMS group at 7 days and 3 months after surgery,and ABI growth value of the DES group was higher than that of the BMS group at 6,12 and 24 months after surgery(P<0.05).There was no significant difference in the primary patency rate at 6 months after surgery,However,the primary patency rate in DES group was higher than that in BMS group at 12 and 24 months after surgery(91.7%vs.65.2%,83.3%vs.56.5%,P<0.05).For the target lesion revascularization rate of the two groups,DES group had a significant advantage over BMS group(4.0%vs.26.1%,P<0.05).Conclusion DES had better clinical efficacy and advantage over bare metal stent for the treatment of femoral popliteal arteriosclerosis obliterans.

关 键 词：动脉硬化闭塞 药物洗脱支架 金属裸支架 股腘动脉 

分 类 号：R543.5[医药卫生—心血管疾病]