加味桂枝茯苓汤联合GnRHa治疗子宫内膜异位症的疗效及对性激素与体液免疫功能的影响  

Curative effect of modified Guizhi Fuling Decoction combined with GnRHa in the treatment of endometriosis and its influence on sex hormones and humoral immune function

作　　者：孙炎华 SUN Yan-hua(Nanjing Gaochun Hospital of Traditional Chinese Medicine,Nanjing 211300,China)

机构地区：[1]南京市高淳中医院,211300

出　　处：《中国实用医药》2023年第22期121-124,共4页China Practical Medicine

摘　　要：目的探析加味桂枝茯苓汤与促性腺激素释放激素激动剂(GnRHa)联合治疗子宫内膜异位症(EMS)的疗效及对性激素与体液免疫功能的影响。方法94例EMS患者,随机分成对照组与观察组,每组47例。对照组采用GnRHa治疗,观察组采用GnRHa联合加味桂枝茯苓汤治疗。比较两组中医症状积分、性激素水平、体液免疫功能以及不良反应发生情况、临床疗效。结果观察组总有效率91.49%高于对照组的70.21%,差异有统计学意义(P<0.05)。治疗后,对照组的痛经评分为(0.89±0.26)分、盆腔压痛评分为(0.78±0.19)分、非经期盆腔痛评分为(0.79±0.25)分、骶韧带触痛结节评分为(0.90±0.22)分,观察组的痛经评分为(0.35±0.13)分、盆腔压痛评分为(0.44±0.15)分、非经期盆腔痛评分为(0.38±0.19)分、骶韧带触痛结节评分为(0.42±0.09)分。治疗后,观察组痛经、盆腔压痛、非经期盆腔痛、骶韧带触痛结节评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组孕酮(7.45±1.46)nmol/L、催乳素(8.12±1.51)μg/L、雌二醇(224.60±19.37)pmol/L、促黄体生成素(2.58±0.33)U/L、卵泡生成素(3.05±0.57)U/L、补液C3(0.61±0.40)g/L、补体C4(0.29±0.01)g/L均低于对照组的(10.37±0.92)nmol/L、(11.57±2.93)μg/L、(253.08±21.42)pmol/L、(3.91±0.52)U/L、(4.89±1.25)U/L、(0.82±0.33)g/L、(0.38±0.05)g/L,差异有统计学意义(P<0.05);两组治疗后免疫球蛋白G、免疫球蛋白M比较,差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论EMS患者在接受加味桂枝茯苓汤与GnRHa联合治疗后效果明显提高,值得临床推广。Objective To explore the curative effect of modified Guizhi Fuling Decoction combined with gonadotropin-releasing hormone agonist(GnRHa)in the treatment of endometriosis(EMS)and its influence on sex hormones and humoral immune function.Methods A total of 94 patients with EMS were randomly divided into a control group and an observation group,with 47 cases in each group.The control group was treated with GnRHa,and the observation group was treated with GnRHa and modified Guizhi Fuling Decoction.The traditional Chinese medicine symptom score,sex hormone level,humoral immune function,occurrence of adverse reactions and clinical efficacy were compared between the two groups.Results The total effective rate of the observation group was 91.49%,which was higher than that of 70.21%of the control group,and the difference was statistically significant(P<0.05).After treatment,in the control group,the dysmenorrhea score was(0.89±0.26)points,the pelvic tenderness score was(0.78±0.19)points,the non-menstrual pelvic pain score was(0.79±0.25)points,and the sacral ligament tenderness node score was(0.90±0.22)points;in the observation group,the dysmenorrhea score was(0.35±0.13)points,the pelvic tenderness score was(0.44±0.15)points,the non-menstrual pelvic pain score was(0.38±0.19)points,and the sacral ligament tenderness node score was(0.42±0.09)points.After treatment,the scores of dysmenorrhea,pelvic tenderness,non-menstrual pelvic pain and sacral ligament tenderness node in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the observation group had progesterone of(7.45±1.46)nmol/L,prolactin of(8.12±1.51)μg/L,estradiol of(224.60±19.37)pmol/L,luteinizing hormone of(2.58±0.33)U/L,follicle stimulating hormone of(3.05±0.57)U/L,complement C3 of(0.61±0.4)0)g/L and complement C4 of(0.29±0.01)g/L,which were lower than those of(10.37±0.92)nmol/L,(11.57±2.93)μg/L,(253.08±21.42)pmol/L,(3.91±0.52)U/L,(4.89±1.25)U/L,(4.89±1.25)U/L

关 键 词：促性腺激素释放激素激动剂 子宫内膜异位症 加味桂枝茯苓汤 体液免疫功能 性激素 

分 类 号：R711.71[医药卫生—妇产科学]