血清Annexin Ⅱ、CRP及H-FABP水平预测冠心病合并房颤患者发生主要不良心脏事件的价值  

Value of serum AnnexinⅡ,CRP and H-FABP in predicting major adverse cardiac events in patients with coronary heart disease complicated by atrial fibrillation

作　　者：张建建 康杰[2] Zhang Jianjian;Kang Jie(Department of Internal Medicine,Jinan Second People’s Hospital,Jinan 250000,China;Department of Internal Medicine,Jinan Nationalities Hospital,Jinan 250012,China)

机构地区：[1]济南市第二人民医院内科,济南250000 [2]济南市民族医院内科,济南250012

出　　处：《中国实用医刊》2023年第19期5-8,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清膜联蛋白A2(AnnexinⅡ)、C反应蛋白(CRP)及心脏型脂肪酸结合蛋白(H-FABP)预测冠心病合并房颤患者发生主要不良心脏事件(MACE)的价值。方法抽取2018年6月至2021年6月济南市第二人民医院收治的冠心病合并房颤患者186例,对患者开展为期1年随访,根据患者住院和随访期间是否出现MACE事件分为发生MACE组(98例)和未发生MACE组(88例)。比较两组患者血清AnnexinⅡ、CRP及H-FABP水平,采用受试者工作特征曲线分析血清AnnexinⅡ、CRP及H-FABP对冠心病合并房颤患者MACE事件的预测价值。结果与未发生MACE组比较,MACE组患者血清AnnexinⅡ、CRP、H-FABP水平显著增高(P<0.05);血清AnnexinⅡ、CRP联合H-FABP预测MACE事件的曲线下面积、灵敏度、特异度、约登指数分别为0.846、79.1%、81.6%、0.607,均高于各项单独检测。结论血清AnnexinⅡ、CRP、H-FABP联合对冠心病合并房颤患者MACE事件的预测有较高临床价值。Objective To investigate the value of serum annexin A2(AnnexinⅡ),C-reactive protein(CRP)and heart-type fatty acid-binding protein(H-FABP)in predicting major adverse cardiac events(MACE)in patients with coronary heart disease complicated by atrial fibrillation.Methods A total of 186 patients with coronary heart disease complicated by atrial fibrillation admitted to Jinan Second People’s Hospital from June 2018 to June 2021 were selected and followed up for 1 year.According to the occurrence of MACE during hospitalization and follow-up,the 186 patients were divided into MACE group(98 cases)and non-MACE group(without MACE,88 cases).Levels of serum AnnexinⅡ,CRP and H-FABP were compared between two groups,and the receiver operating characteristic curve was used to evaluate the predictive value of three indicators for MACE in patients with coronary heart disease and atrial fibrillation.Results Compared with the non-MACE group,serum AnnexinⅡ,CRP and H-FABP in the MACE group were significantly elevated(P<0.05).The area under the curve,sensitivity,specificity,and Youden index of the combination of serum AnnexinⅡ,CRP and H-FABP in predicting MACE were 0.846,79.1%,81.6%and 0.607,respectively,which were all remarkably higher than those of the three single indications.Conclusions Combined detection of AnnexinⅡ,CRP and H-FABP has high clinical value in predicting MACE in patients with coronary heart disease complicated by atrial fibrillation.

关 键 词：冠心病 房颤 膜联蛋白A2 C反应蛋白 心脏型脂肪酸结合蛋白 

分 类 号：R541[医药卫生—心血管疾病]