氯胺酮相关膀胱炎的研究进展  

Advances in ketamine-associated cystitis

作　　者：吴静思 冯妍 朱辉 邓斌 陈羽 侯立朝 WU Jing-si;FENG Yan;ZHU Hui;DENG Bin;CHEN Yu;HOU Li-chao(Department of Anesthesiology,Xiang-an Hospital of Xiamen University,Xiamen FUJIAN 361101,China;Department of Anesthesiology,Shanghai General Hospital,Shanghai Jiao Tong University,SHANGHAI 201620,China;Department of Anesthesiology,Sun Yat-sen University Cancer Center,Guangzhou GUANGDONG 510060,China;Department of Anesthesiology,Dongfeng Hospital,Hubei University of Medicine,Shiyan HUBEI 442008,China)

机构地区：[1]厦门大学附属翔安医院麻醉科,福建厦门361101 [2]上海交通大学附属第一人民医院麻醉科,上海201620 [3]中山大学肿瘤防治中心手术麻醉科,广东广州510060 [4]湖北医药学院附属东风医院麻醉科,湖北十堰442008

出　　处：《中国新药与临床杂志》2023年第11期700-705,共6页Chinese Journal of New Drugs and Clinical Remedies

基　　金：2019年厦门大学研究生教学改革研究项目(JG20190412);厦门市医疗卫生指导性项目(3502Z20209114);福建省海峡医药卫生交流协会重点科研项目(2020HYH10)。

摘　　要：氯胺酮是一种临床常用静脉麻醉药,但该药物会引起欣快感,易成瘾。氯胺酮滥用已成为严重社会问题,随之出现的氯胺酮相关膀胱炎(KC)症状包括尿频、尿急、血尿、排尿困难、排尿后膀胱疼痛及痛觉过敏。KC的发病机制较复杂,可能与氯胺酮对尿路上皮细胞、膀胱血管与神经的毒性作用,以及引起的自身免疫反应、细胞凋亡等有关。发生KC时应及时停用氯胺酮,使用抗胆碱药、非甾体抗炎药、尿路上皮保护剂等,必要时进行手术治疗。Ketamine is a commonly used intravenous anesthetic in clinical practice,but it can cause euphoria and addiction.Ketamine abuse has become a serious social problem.The symptoms of ketamine-associated cystitis(KC)include frequent urination,urgency,hematuria,dysuria,bladder pain after urination and hyperalgesia.The pathogenesis of KC is complex,which may be related to the toxic effects of ketamine on urinary tract epithelial cells,bladder blood vessels and nerves,as well as the autoimmune response and apoptosis.When KC occurs,ketamine should be discontinued in time,and anticholinergic drugs,non-steroidal anti-inflammatory drugs,urinary tract epithelial protective agents,etc.should be used,and surgical treatment should be performed if necessary.

关 键 词：氯胺酮 膀胱炎 麻醉剂相关障碍 炎症 神经毒性 自身免疫反应 

分 类 号：R971[医药卫生—药品]