基于NF-κB通路调控Th1/Th2平衡探讨三子汤治疗支气管哮喘急性发作期的临床研究  

Discussion on the efficacy of Sanzi decoction on acute exacerbation of bronchial asthma based on the regulation of Th1/Th2 balance by NF-κB pathway

作　　者：蒋紫云[1] 孟星汝 周谨希 谢燕小 陶海澜 连乐燊[1] 孙志佳 JIANG Ziyun;MENG Xingru;ZHOU Jinxi;XIE Yanxiao;TAO Hailan;LIAN Leshen;SUN Zhijia(Dongguan Hospital of Guangzhou University of Chinese Medicine,Dongguan 523000,Guangdong,China;The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510370,Guangdong,China)

机构地区：[1]广州中医药大学东莞医院,广东东莞523000 [2]广州中医药大学第三附属医院,广东广州510370

出　　处：《现代中西医结合杂志》2023年第20期2817-2821,2828,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省自然科学基金面上项目(2021A1515010146);东莞市社会科技发展项目(20211800900142);东莞市临床重点专科建设项目。

摘　　要：目的观察三子汤治疗支气管哮喘急性发作期的临床疗效及对核转录因子-κB(NF-κB)通路及Th1/Th2失衡的影响。方法将2020年12月-2022年11月广州中医药大学东莞医院收治的60例哮喘急性发作期患者随机分为治疗组和对照组,每组各30例。对照组给予西医常规治疗,治疗组在对照组治疗基础上给予三子汤治疗,2组均治疗2周。观察比较2组中医证候疗效及治疗前后中医证候积分、外周血嗜酸性粒细胞(EOS)计数、呼出气一氧化氮(FeNO)水平、最大呼气流速(PEF)、第1秒用力呼气容积(FEV_(1))及血清白细胞介素-2(IL-2)、干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)、NF-κB p65水平。结果治疗组总有效率为96.7%(29/30),明显高于对照组的80.0%(24/30),差异有统计学意义(P<0.05)。治疗后2组中医证候积分、外周血EOS计数、FeNO水平及血清IL-4、NF-κB p65水平均较治疗前明显下降(P均<0.05),且治疗组均明显低于对照组(P均<0.05)。治疗后2组PEF、FEV_(1)及血清IL-2、IFN-γ水平均较治疗前明显升高(P均<0.05),且治疗组均明显高于对照组(P均<0.05)。结论三子汤可有效改善支气管哮喘急性发作期患者症状、气道炎症及肺功能,其作用机制与调控NF-κB通路,从而调节Th1/Th2平衡有关。Objective It is to observe the clinical efficacy of Sanzi decoction in the treatment of acute exacerbation of bronchial asthma and its effect on nuclear transcription factor-κB(NF-κB)pathway and Th1/Th2 imbalance.Methods Sixty patients with acute exacerbation of bronchial asthma treated at Dongguan Hospital of Guangzhou University of Chinese Medicine from December 2020 to November 2022 were randomly divided into a treatment group and a control group,with 30 cases in each group.The control group was given conventional treatment with western medicine,and the treatment group was given Sanzi decoction on the basis of the treatment of the control group,and both groups were treated for 2 weeks.The efficacy of traditional Chinese medicine syndrome after treatment,scores of traditional Chinese medicine syndrome,peripheral blood eosinophils(EOS)counts,levels of exhaled nitric oxide(FeNO),peak expiratory flow(PEF),forceful expiratory volume in the first second(FEV_(1)),and serum levels of interleukin-2(IL-2),interferon-γ(IFN-γ),interleukin-4(IL-4),and NF-κB p65 before and after treatment were observed and compared between the two groups.Results The total effective rate of the treatment group was 96.7%(29/30),which was significantly higher than that(80.0%)(24/30)of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of traditional Chinese medicine syndrome,peripheral blood EOS counts,levels of FeNO levels,and serum levels of IL-4 and NF-κB p65 of the two groups were significantly decreased compared with those before treatment(all P<0.05),and the decreases of the treatment group were more significant than those of the control group(all P<0.05).After treatment,PEF,FEV_(1) and serum levels of IL-2,IFN-γof the two groups were significantly increased compared with those before treatment(all P<0.05),and the increases of the treatment groups were more significant than those of the control group(both P<0.05).Conclusion Sanzi decoction can effectively improve the symptoms,airw

关 键 词：三子汤 支气管哮喘 TH1/TH2平衡 核转录因子-κB通路 

分 类 号：R256.12[医药卫生—中医内科学]