新生儿急性胆红素脑病的研究进展  

Research Progress of Neonatal Acute Bilirubin Encephalopathy

作　　者：陈国锋 丁月琴 Chen Guofeng;Ding Yueqin(The Tenth Affiliated Hospital of Southern Medical University(Dongguan People's Hospital),Dongguan 523000,Guangdong Province,China)

机构地区：[1]南方医科大学第十附属医院(东莞市人民医院),广东东莞523000

出　　处：《中国社区医师》2023年第32期10-12,共3页Chinese Community Doctors

摘　　要：急性胆红素脑病是新生儿高胆红素血症的常见并发症。胆红素代谢、血脑屏障通透性、神经元敏感性等是急性胆红素脑病发生的危险因素,脑干神经核团及基底节是主要损伤部位,颅脑MRI及听觉脑干诱发电位等是重要检查方法,而蓝光照射、静脉注射免疫球蛋白及换血疗法是主要治疗方案。该文围绕新生儿急性胆红素脑病的危险因素、病理机制、检查方法、治疗方案作一综述。Acute bilirubin encephalopathy is the common complication of neonatal hyperbilirubinemia.Bilirubin metabolism,blood-brain barrier permeability,and neuronal sensitivity are risk factors for the occurrence of acute bilirubin encephalopathy,brainstem nerve nuclei and basal ganglia are the main injury sites,cranial MRI and auditory brainstem evoked potentials are important examination methods,and blue light irradiation,intravenous immunoglobulin and exchange transfusion are the main treatment options.This article reviews the risk factors,pathological mechanism,examination methods and treatment protocol of acute neonatal bilirubin encephalopathy.

关 键 词：新生儿 急性胆红素脑病 危险因素 检查方法 病理机制 治疗方案 

分 类 号：R722.1[医药卫生—儿科]