核酸农药纳米递送系统研究进展  

Advance of nucleic acid pesticide delivery systems mediated by nanomaterial

作　　者：何承帅 张辉[1] 吴顺凡[1] 高云昊 高聪芬[1] HE Chengshuai;ZHANG Hui;WU Shunfan;GAO Yunhao;GAO Congfen(State&Local Joint Engineering Research Center of Green Pesticide Invention and Application,College of Plant Protection,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学绿色农药创制与应用技术国家地方联合工程研究中心,植物保护学院,南京210095

出　　处：《农药学学报》2023年第6期1179-1197,1369,共20页Chinese Journal of Pesticide Science

基　　金：国家重点研发计划项目“重要病虫害抗药性机制与治理技术研发”(2022YFD1400900)。

摘　　要：随着现代社会的发展,人们对健康和环保的关注度逐渐提高,开发绿色环保的新型农药是未来农药领域发展的总体趋势。与传统化学农药相比,核酸农药具备靶向性强、环境兼容性好、开发简便等诸多优势,在有害生物可持续治理方面具有巨大的应用前景。然而,如何有效地将核酸农药效应分子(dsRNA/siRNA)递送至目标生物的组织或细胞中尚是核酸农药应用上极具挑战性的问题。近年来,多种类型的纳米材料在提高核酸农药递送效率方面表现出巨大的潜力。本文就核酸农药的应用方式与挑战、核酸农药的产业化进展、核酸农药纳米递送系统的研究进展及其安全风险进行了综述,并对核酸农药纳米递送系统的前景和挑战进行了展望。With the development of science and technology,more attention has been focused on human health and environmental safety.Green pesticides will be the development trend of pesticides in the future.Compared to traditional chemical pesticides,specific targeting,environmental safety,and easy development were among the advantages of nucleic acid pesticides.However,there are great challenges in delivering the effector molecules of nucleic acid pesticides(dsRNA/siRNA)to the tissues or cells of target organisms.In recent years,nucleic acid pesticide delivery systems based on various types of nanomaterials have been developed to address this issue.The approaches and challenges of applying nucleic acid pesticides,as well as the advantages,mechanisms,and novel nanomaterials used in nanomaterial-mediated nucleic acid pesticide delivery systems,are reviewed in this paper.The prospects of nanomaterial-mediated delivery systems for nucleic acid pesticides are also prospected.

关 键 词：核酸农药 dsRNA/siRNA 纳米材料 递送系统 

分 类 号：Q789[生物学—分子生物学] TQ459[化学工程—农药化工]