纳米羟基磷灰石对氯氧镁水泥降解性和体外生物活性的影响  

Effect of Nano-hydroxyapatite on Degradability and in Vitro Bioactivity of Magnesium Oxychloride Cement

作　　者：李航 廖建国[1] 毛艳瑞 阮文强 LI Hang;LIAO Jianguo;MAO Yanrui;RUAN Wenqiang(School of Materials Science and Engineering,Henan Polytechnic University,Jiaozuo 454000,Henan,China)

机构地区：[1]河南理工大学材料科学与工程学院,河南焦作454000

出　　处：《材料导报》2023年第24期36-40,共5页Materials Reports

基　　金：河南省科技攻关项目(222102310112,222102320028);河南省教育厅基础研究计划(19A430015,19B430004);河南省高校基本科研业务费专项资金(NSFRF180311)。

摘　　要：氯氧镁水泥(MOC)具有强度高、粘结性好和无细胞毒性等优点,可应用于骨修复材料领域。本工作将生物活性纳米羟基磷灰石(n-HAp)与MOC复合,研究了n-HAp掺量对MOC耐水性、降解性和生物活性的影响。结果显示n-HAp的最佳掺量为MgO质量的10%。在模拟体液(SBF)中浸泡28 d后,10%n-HAp-MOC的抗压强度((29.9±1.8)MPa)和软化系数(0.39)均高于未改性组MOC,质量损失率(34.5%)低于未改性组MOC,说明n-HAp的掺入增强了MOC的耐水性,从而有效地减缓了其降解速率。通过SBF的Ca^(2+)、PO_(4)^(3-)浓度变化和XRD图可知,MOC表面可沉积生成HAp晶体,即MOC具有生物活性,且n-HAp的掺入促进新生HAp晶体在MOC表面矿化沉积,增强了MOC的生物活性。Magnesium oxychloride cement(MOC)has the advantages of high strength,good adhesion and non-cytotoxicity,which can be applied in the field of bone repair materials.In this study,nano-hydroxyapatite(n-HAp),a bioactive material,was incorporated into MOC and the effects of n-HAp on water resistance,degradability and bioactivity of MOC were investigated.It was found that the best amount of n-HAp was 10%by mass of magnesium oxide.After soaking in simulated body fluid(SBF)for 28 d,the compressive strength((29.9±1.8)MPa)and softening coefficient(0.39)of 10%n-HAp-MOC were higher than those of the unmodified MOC,and the mass loss rate(34.5%)was lower than that of the unmodified MOC.The addition of n-HAp enhanced the water resistance of MOC and thereby reduced effectively its degradation rate.Based on XRD analysis and ion concentration change,hydroxyapatite crystals could be deposited on the surface of MOC,indicating that MOC has biological activity.The incorporation of n-HAp promoted the growth of mineralized HAp crystals deposited on the surface of MOC and enhanced the bioactivity of MOC.

关 键 词：骨水泥 氯氧镁水泥 纳米羟基磷灰石 耐水性 降解性 体外生物活性 

分 类 号：TB321[一般工业技术—材料科学与工程]