绞股蓝总苷片联合依折麦布治疗高脂血症的临床研究  

Clinical study on Jiaogulan Zongdai Tablets combined with ezhemai in treatment of hyperlipidemia

作　　者：张婧[1] 晏玲[1] 周祥 ZHANG Jing;YAN Ling;ZHOU Xiang(Department of Endocrine and Metabolic Diseases,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430000,China;Departmentof Clinical Laboratory,Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430000,China)

机构地区：[1]武汉市中医医院内分泌代谢病科,湖北武汉430000 [2]武汉市中医医院检验科,湖北武汉430000

出　　处：《现代药物与临床》2023年第11期2751-2755,共5页Drugs & Clinic

基　　金：湖北省科技厅科技计划项目(2018CFB707)。

摘　　要：目的 探讨绞股蓝总苷片联合依折麦布治疗高脂血症的临床疗效。方法 选取2020年12月—2022年12月武汉市中医医院收治的136例高血脂症患者,按照数字随机法将患者分对照组(68例)和治疗组(68例)。对照组患者口服依折麦布片,10 mg/次,1次/d。在对照组的基础上,治疗组口服绞股蓝总苷片,3片/次,3次/d。两组连续服药15 d。观察两组患者临床疗效,比较治疗前后两组患者症状好转时间,血脂总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,血管内皮功能内皮素-1(ET-1)、一氧化氮(NO)、血管假性血友病因子(v WF)和白细胞介素6(IL-6)水平。结果 治疗后,治疗组临床有效率为98.53%,明显高于对照组(85.29%,P<0.05)。治疗后,治疗组症状好转时间均明显早于对照组(P<0.05)。治疗后,两组患者血脂TG、TC和LDL-C水平明显降低,而HDL-C水平明显升高(P<0.05),且治疗组血脂水平明显好于对照组(P<0.05)。治疗后,两组血管内皮功能ET-1、vWF、IL-6水平明显降低,而NO水平明显升高(P<0.05),且治疗组ET-1、vWF、IL-6和NO水平均明显好于对照组(P<0.05)。结论 绞股蓝总苷片联合依折麦布治疗高脂血症可促进临床症状有效改善,降低高血脂症状态,对内皮功能调节增强。Objective To investigate the effects of Jiaogulan ZongdaiTablets and ezhemai in treatment of hyperlipidemia.Methods Patients(136 cases)with hyperlipidemia in Wuhan Hospital of Traditional Chinese Medicine from December 2020 to December 2022 were divided into control group(68 cases)and treatment group(68 cases)according to numerical random method.Patients in the control group were po administered with Ezetimibe Tablets,10 mg/time,once daily.Patients in the treatment group were po administered with Jiaogulan Zongdai Tablets on the basis of the control group,3 tablets/time,three times daily.Patients in two groups were treated for 15 d.After treatment,the clinical evaluation was evaluated,and the improvement time of symptom,the levels of blood lipids TG,TC,LDL-C and HDL-C,the levels of vascular endothelial function indexes ET-1,vWF,IL-6 and NO in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.53%,which was significantly higher than that of the control group(85.29%,P<0.05).After treatment,the improvement time of symptom in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the levels of blood lipids TG,TC and LDL-C in two groups were significantly decreased,while the level of HDL-C were significantly increased(P<0.05),the level of blood lipid in the treatment group was significantly better than that in the control group(P<0.05).After treatment,the levels of ET-1,vWF and IL-6 of vascular endothelial function were significantly decreased,while the level of NO was significantly increased in two groups(P<0.05),and the levels of ET-1,vWF,IL-6 and NO in the treatment group were significantly better than those in the control group(P<0.05).Conclusion The synergistic treatment of ezhemai and Jiaogulan Zongdai Tablets is effective in treatment of hyperlipidemia,which can effectively improve clinical symptoms,reduce the state of hyperlipidemia,and enhance the regulation of endothelial function.

关 键 词：绞股蓝总苷片 依折麦布片 高脂血症 脂代谢 内皮功能 血管假性血友病因子 

分 类 号：R973[医药卫生—药品]