天然化合物-O-甲基转移酶的研究进展  

Research progress on natural product-O-methyltransferase

作　　者：黄玉 刘李[2] HUANG Yu;LIU Li(Department of Pharmacy,Children’s Hospital of Nanjing Medical University,Nanjing 210008,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]南京医科大学附属儿童医院药学部,江苏南京210008 [2]中国药科大学药学院,江苏南京210009

出　　处：《现代药物与临床》2023年第11期2890-2898,共9页Drugs & Clinic

基　　金：国家自然科学基金资助项目(82173884)。

摘　　要：天然化合物-O-甲基转移酶(NPOMT)是一种以S-腺苷甲硫氨酸(SAM)为供体,靶向天然化合物中氧原子的甲基转移酶,在体内主要以两种形式存在:儿茶酚-O-甲基转移酶(COMT)、羟基吲哚-O-甲基转移酶(HIOMT)。COMT、HIOMT代谢多种内源性物质(主要是邻苯二酚类以及羟基吲哚类化合物),参与体内信号转导、生长增殖、能量代谢、节律调控等一系列生理学过程。对NPOMT的体内分布和表达、底物、功能、在体内的表达调控和抑制剂进行综述,以期为用于治疗相关代谢性疾病的NPOMT特异性激动剂/抑制剂的研发以及相关疾病的诊断和预后评估提供参考。Natural product-O-methyltransferases (NPOMT) is a methyltransferase using S-adenosylmethionine (SAM) as a donor that targets the O atom in natural compounds. NPOMT exists in main two forms in the body: catechol-O-methyltransferase (COMT) and hydroxyindole-O-methyltransferase (HIOMT). COMT and HIOMT metabolizes a variety of endogenous substances (mainly catechol and hydroxy-indole compounds), and participates in a series of physiological processes such as signal transduction, growth and proliferation, energy metabolism, and rhythm regulation. This article reviews distribution and expression in vivo, substrates, functions, expression regulation in vivo, and inhibitors of NPOMT, with the aim of providing reference for the development of NPOMT specific agonists/inhibitors for treatment of related metabolic diseases, as well as for the diagnosis and prognosis evaluation of related diseases.

关 键 词：儿茶酚-O-甲基转移酶 羟基吲哚-O-甲基转移酶 分布 底物 功能 表达调控 抑制剂 

分 类 号：R977[医药卫生—药品]