葛根素防治骨质疏松症的作用机制研究进展  

Research progress on mechanism of puerarin in prevention and treatment of osteoporosis

作　　者：张露新 孟璐 张虹 ZHANG Lu-xin;MENG Lu;ZHANG Hong(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Luoyang Orthopedic-Traumatological Hospital/Henan Provincial Orthopedic Hospital,Luoyang 471002,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南省洛阳正骨医院(河南省骨科医院),河南洛阳471002

出　　处：《现代药物与临床》2023年第11期2899-2902,共4页Drugs & Clinic

基　　金：河南省中医药科学研究专项课题(2022ZY1137)。

摘　　要：我国骨质疏松症的患病率高,是老年患者致残和致死的主要原因之一。葛根素是葛根中主要活性成分,可促进成骨细胞的增殖分化、抑制骨吸收和破骨细胞的分化形成、促进骨髓间充质干细胞向成骨分化、发挥雌激素样作用。综述了葛根素防治骨质疏松症的作用机制研究进展,为深入开展葛根素治疗骨质疏松症的基础研究和新药开发提供参考。The prevalence of osteoporosis in China is high, and is one of the main causes of disability and death in elderly patients. Puerarin is the main active ingredient in Puerariae Radix, which can promote the proliferation and differentiation of osteoblasts, inhibit bone resorption and osteoclast differentiation, promote bone marrow mesenchymal stem cells to differentiate into osteoblasts, and exert estrogen like effects. This article reviews the research progress on mechanism of puerarin in preventing and treating osteoporosis, providing reference for further basic research and new drug development of puerarin in treating osteoporosis.

关 键 词：葛根素 骨质疏松 成骨细胞 破骨细胞 骨髓间充质干细胞 雌激素样作用 

分 类 号：R982[医药卫生—药品]