Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer  

作　　者：Qiuhui YANG Yeqin FU Jiaxuan WANG Hongjian YANG Xiping ZHANG 

机构地区：[1]Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou,310022,China [2]Postgraduate Training Base Alliance of Wenzhou Medical University(Zhejiang Cancer Hospital),Hangzhou,310022,China [3]The First Clinical Medical College,Shanxi Medical University,Jinzhong,030600,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第11期985-997,共13页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Zhejiang Provincial Natural Science Foundation of China (No.LBY21H160001).

摘　　要：Sentinel lymph nodes(SLNs)are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage.The pathological status of these LNs can predict that of the entire axillary lymph node.Therefore,the accurate identification of SLNs is necessary for sentinel lymph node biopsy(SLNB)to replace axillary lymph node dissection(ALND).The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs.Some of the SLN tracers that have been identified include radioisotope,nano-carbon,indocyanine green(ICG),and methylene blue(MB).However,these tracers have certain limitations,such as pigmentation,radiation dangers,and the requirement for costly detection equipment.Ultrasound contrast agents(UCAs)have good specificity and sensitivity,and thus can compensate for some shortcomings of the mentioned tracers.This technique is also being applied to SLNB in patients with breast cancer,and can even provide an initial judgment on SLN status.Contrast-enhanced ultrasound(CEUS)has the advantages of high distinguishability,simple operation,no radiation harm,low cost,and accurate localization;therefore,it is expected to replace the traditional biopsy methods.In addition,it can significantly enhance the accuracy of SLN localization and shorten the operation time.

关 键 词：Breast cancer Sentinel lymph node(SLN) Contrast-enhanced ultrasound(CEUS) Ultrasound contrast agent(UCA) 

分 类 号：R737.9[医药卫生—肿瘤]