Pseudomonas aeruginosa-induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species(ROS)-dependent way  

作　　者：Haitao YANG Yan WANG Hui FAN Feixue LIU Huimiao FENG Xueqing LI Mingyi CHU Enzhuang PAN Daoyang TENG Huizhen CHEN Jingquan DONG 

机构地区：[1]Jiangsu Key Laboratory of Marine Bioresources and Environment,Co-Innovation Center of Jiangsu Marine Bio-Industry Technology,Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,College of Pharmacy,Jiangsu Ocean University,Lianyungang,222005,China [2]Department of Medicine Laboratory,the Second People’s Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical University,the Second People’s Hospital of Lianyungang City,Lianyungang,222000,China [3]Institute of Neuroscience,the First People’s Hospital of Lianyungang,Lianyungang,222000,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第11期1027-1036,共10页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Basic Science (Natural Science)Research Project of Higher Education of Jiangsu Province (No.21KJB230001);the Open-End Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening (No.HY202101);the Lianyungang City Science and Technology Bureau Science and Technology Plan (Social Development)Project (No.SF2140);the 2022 Medical Research guiding Project of Jiangsu Provincial Health Commission (No.Z2022070);the 2023 Jiangsu Graduate Research Innovation Plan Project (No.SJCX23_1838);the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

摘　　要：Pseudomonas aeruginosa belongs to the genus Pseudomonas and is a common Gram-negative,exclusively aerobic,conditionally pathogenic bacterium with the characteristics of easy colonization,mutation,and multidrug resistance(Deng et al.,2015;Azam and Khan,2019;Jurado-Martin et al.,2021).

关 键 词：belongs REACTIVE resistance 

分 类 号：Q946.5[生物学—植物学]