海南省五指山市人群幽门螺旋杆菌感染现状调查及相关危险因素分析  

Investigation on the current status of Helicobacter pylori infection and analysis of related risk factors in the population of Wuzhishan City

作　　者：曾凡 张大涯 陈世锔 郭晓阳 陈晨 黄士美 陈润祥 张晓冬 李达 汪琦 熊建新 白飞虎 ZENG Fan;ZHANG Da-yan;CHEN Shi-ju;GUO Xiao-yang;CHEN Chen;HUANG Shi-mei;CHEN Run-xiang;ZHANG Xiao-dong;LI Da;WANG Qi;XIAONG Jian-xin;BAI Fei-hu(Graduate School,Hainan Medical University,Haikou 571199,China;Department of Gastroenterology,Hainan Second People′s Hospital,Haikou 570216,China;Department of Gastroenterology,The Second Affiliated Hospital of Hainan Medical University,Haikou 570216,China;The Gastroenterology Clinical Medical Center of Hainan Province,Haikou 570216,China)

机构地区：[1]海南医学院研究生院,571199 [2]海南省第二人民医院消化内科,570216 [3]海南省消化疾病临床研究中心,570216 [4]海南医学院第二附属医院消化内科,570216

出　　处：《现代消化及介入诊疗》2023年第8期957-961,共5页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：海南省临床医学中心建设项目资助(2021818);海南省院士创新平台科研项目资金资助(YSPTZX202313);海南省卫生健康行业科研项目资助(22A200078);海南省研究生创新科研课题(Qhyb2022-133);海南医学院研究生创新科研课题(HYYB2022A18)。

摘　　要：目的了解五指山市自然人群幽门螺旋杆菌(Helicobacter pylori,Hp)感染的流行病学情况,从多种潜在影响及致病因素分析,为防治幽门螺旋杆菌感染提供科学依据。方法采用整体分层随机抽样法,对528名参检人员应用碳^(14)-尿素呼气试验(^(14)C-UBT)进行Hp检测,并对参检人员进行问卷调查的方式,分析影响Hp感染的高危因素。结果五指山市人群总感染率为42%。年龄(χ^(2)=7.312,P=0.032)、共用餐具(χ^(2)=6.363,P=0.024)、便后洗手习惯(χ^(2)=6.438,P=0.023),进食瓜果蔬菜(χ^(2)=8.438,P=0.014)和睡眠质量好(χ^(2)=12.638,P=0.049)与Hp感染有相关性。二元logistic回归分析后,年龄(β=0.583)、共用餐具(β=0.438)、睡眠状态好(β=0.193)和进食瓜果蔬菜(β=0.467)是影响Hp感染的独立相关因素。结论五指山市幽门螺旋杆菌感染率为42%,低于全国平均水平。中年人群和共用餐具是影响Hp感染的独立危险因素,进食瓜果蔬菜和睡眠质量好是Hp感染的独立保护因素。Objective To understand the epidemiology of H.pylori infection in the natural population of Wuzhishan City,and to provide scientific basis for the prevention and treatment of H.pylori infection from the analysis of various potential influences and pathogenic factors.Methods Using the overall stratified random sampling method,the ^(14)C breath test(^(14)C-UBT)combined with a questionnaire was used to test 528 participant for H.pylori and analyze the high-risk factors affecting H.pylori infection.Results The total infection rate in the Wuzhishan population was 42%.Age(χ^(2)=7.312,P=0.032),sharing of utensils(χ^(2)=6.363,P=0.024),hand washing habit after defecation(χ^(2)=6.438,P=0.023),eating fruits and vegetables(χ^(2)=8.438,P=0.014)and good sleep quality(χ^(2)=12.638,P=0.049)were associated with H.pylori infection correlation.After binary logistic regression analysis,age(β=0.583),sharing of utensils(β=0.438),good sleep status(β=0.193)and consumption of fruits and vegetables(β=0.467)were independently associated factors affecting H.pylori infection.Conclusion The prevalence of H.pylori infection in Wuzhishan City was 42%,which was lower than the national average.Middle-aged population and sharing of utensils were independent risk factors influencing H.pylori infection,and consumption of fruits and vegetables and good sleep quality were independent protective factors for H.pylori infection.

关 键 词：幽门螺旋杆菌 流行病学 ^(14)C尿素呼气试验 五指山市 

分 类 号：R181.2[医药卫生—流行病学]