利用纳米材料提高光动力疗效的研究进展  

Research Progress on Improving Photodynamic Therapy by Using Nanomaterials

作　　者：冯玫 郭佳丽 王馨 李扬 李晓京 张宽收[1] FENG Mei;GUO Jiali;WANG Xin;LI Yang;LI Xiaojing;ZHANG Kuanshou(Institute of Opto-electronics,Shanxi University,Taiyuan 030006,China;General Medicine Department,Shanxi Bethune Hospital,Taiyuan 030006,China)

机构地区：[1]山西大学光电研究所,山西太原030006 [2]山西白求恩医院全科医学科,山西太原030006

出　　处：《山西大学学报（自然科学版）》2023年第6期1344-1357,共14页Journal of Shanxi University(Natural Science Edition)

基　　金：国家自然科学基金(61875113);量子光学与光量子器件国家重点实验室开放课题(KF202002)。

摘　　要：光动力疗法是一种集微创、高选择性和低全身毒性等优点于一身的新兴疗法,近年来被广泛应用于实体瘤的临床治疗。然而,光动力治疗的触发条件以及光敏剂本身的特点限制了其治疗效果。利用纳米技术与光动力疗法相结合,可以突破光动力疗法的限制,大大提升其治疗效果并减小副作用。本文针对光动力治疗中治疗效果的主要影响因素以及基于纳米材料的解决方案,对纳米材料在光动力治疗中的应用与发展进行了综述,并对未来的研究进行了展望。Photodynamic therapy(PDT)is an emerging therapy with advantages of minimally invasive,high selectivity and low systemic toxicity,which has been widely used in the clinical treatment of solid tumors in recent years.However,the triggering conditions of photodynamic therapy and the characteristics of photosensitizer limit its therapeutic effect.The combination of nanotechnology and photodynamic therapy can break the limitations of photodynamic therapy,greatly improve the therapeutic effect and reduce the side effects.In this paper,aiming at the main factors affecting the therapeutic effect in photodynamic therapy and the solutions based on nanomaterials,the application and development of nanomaterials in photodynamic therapy are reviewed,and the future research is prospected.

关 键 词：光动力治疗 纳米材料 靶向性 穿透深度 乏氧 

分 类 号：R318.51[医药卫生—生物医学工程]