阻塞性睡眠呼吸暂停与中枢和外周化学敏感性:发病机制中的重要环节  

Obstructive sleep apnea and central/peripheral chemosensitivity:an essential part of pathophysiological mechanisms

作　　者：戴璐 肖毅[1] Dai Lu;Xiao Yi(Department of Respiratory and Critical Care Medicine,Peking Union Medical College Hospital,Peking Union Medical College Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院、北京协和医院呼吸与危重症医学科,北京100730

出　　处：《中华结核和呼吸杂志》2023年第12期1151-1153,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：呼吸调控异常是阻塞性睡眠呼吸暂停(OSA)的重要病理生理机制之一,化学感受器的活动是呼吸调控中的重要环节。化学敏感性对OSA的病情严重程度、合并症发生及预后均存在显著影响,针对降低化学敏感性的治疗方案能更有效地推进OSA的个体化、精准化治疗。目前国内外对此方向的研究偏少,尤其国内仍处于较早的探索阶段,着眼OSA化学敏感性进行进一步探索将是目前及未来睡眠领域研究的新兴方向,也将会是一大挑战。Unstable ventilatory control is one of the key pathophysiological mechanisms of obstructive sleep apnea(OSA),and the activity of chemoreceptors is an important part of ventilatory control.Chemosensitivity has a significant impact on the severity and prognosis of OSA,and the incidence of comorbidities.The focus on reducing chemosensitivity can be seen as an emerging theme to promote individualized and precise treatment of OSA.Further exploration of chemosensitivity in OSA will be an emerging direction and a major challenge for current and future research in the field of sleep.

关 键 词：阻塞性睡眠呼吸暂停 化学敏感性 病理生理机制 病情严重程度 化学感受器 呼吸调控 精准化治疗 发病机制 

分 类 号：R766[医药卫生—耳鼻咽喉科]