发生在非免疫抑制宿主的播散性诺卡菌病1例  

A case of disseminated nocardiosis in a non‑immunosuppressed host

作　　者：魏维 程璘令[1] 江颖[1] Wei Wei;Cheng Linling;Jiang Ying(Department of Respiratory and Critical Care Medicine,State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China;Department of Respiratory and Critical Care Medicine,Anyue CountyPeople′s Hospital,Anyue 642350,China)

机构地区：[1]广州医科大学附属第一医院、广州呼吸健康研究院呼吸疾病国家重点实验室/国家呼吸系统疾病临床医学研究中心、国家呼吸医学中心呼吸与危重症医学科,广州510120 [2]安岳县人民医院呼吸与危重症医学科,安岳642350

出　　处：《中华结核和呼吸杂志》2023年第12期1245-1248,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：诺卡菌为一种机会性致病菌,多见于免疫抑制宿主,在非免疫抑制宿主发生播散性感染较为少见。本文报道1例非免疫抑制宿主发生播散性诺卡菌感染的病例,其初始影像学与肿瘤全身转移极其相似,多次取活检未见肿瘤细胞,考虑特殊病原体感染,最终通过腰椎活检组织宏基因组二代测序确诊为诺卡菌感染。本文总结了播散性诺卡菌病的临床特点、诊断方法以及治疗手段,希望临床医生能加强对该疾病认识,避免误诊、漏诊。Nocardia is an opportunistic pathogen that most commonly affects immunosuppressed hosts,while disseminated infections in healthy hosts are rare.In this paper,we described a case of disseminated Nocardia infection in a non‑immunosuppressed host whose initial imaging was strikingly similar to systemic metastasis from a tumor.Since no tumor cells were found in any of the numerous biopsies taken,we considered infection by specific pathogens before metagenomic next‑generation sequencing of a lumbar spine tissue biopsy finally confirmed the diagnosis of Nocardia infection.To help doctors better understand this condition and avoid misdiagnosis a,this article provided a summary of the clinical characteristics,diagnostic techniques,and therapeutic options for disseminated nocardiosis.

关 键 词：播散性 活检组织 诺卡菌 临床医生 病原体感染 宏基因组 影像学 二代测序 

分 类 号：R519[医药卫生—内科学]