基于细胞死亡方式Parthanatos的相关疾病治疗策略的研究进展  

Research progress on treatment strategies for related diseases based on Parthanatos

作　　者：路紫瑶(综述) 马传福 巴雪青(审校) LU Ziyao;MA Chuanfu;BA Xueqing(School of Food and Biology Changchun Polytechnic,Changchun 130000,Jilin Province,China;不详)

机构地区：[1]长春职业技术学院食品与生物学院,吉林长春130000 [2]长春市就业训练中心,吉林长春130000 [3]东北师范大学生命科学学院,吉林长春130000

出　　处：《中国生物制品学杂志》2023年第11期1397-1402,1408,共7页Chinese Journal of Biologicals

基　　金：国家自然科学基金(31970686)。

摘　　要：Parthanatos是一种程序性细胞死亡方式,根据其分子机制也被称为多聚ADP核糖聚合酶1[poly(ADP-ribose)polymerase 1,PARP1]介导的凋亡诱导因子(apoptosis-inducing factor,AIF)和巨噬细胞迁移抑制因子(macrophage migration inhibitory factor,MIF)依赖的细胞死亡方式。Parthanatos是多种神经退行性疾病发病的主要原因,如帕金森症(Parkinson’s disease,PD)、阿尔莫茨海默症(Alzheimer’s disease,AD)、运动神经元病等,其还参与到部分肿瘤如肺癌、乳腺癌的发病过程中。因此,深入了解Parthanatos的分子机制对研究相关疾病的治疗策略至关重要。近年来有研究发现,通过调节Parthanatos中的关键蛋白PARP1、AIF、MIF进而有效调控Parthanatos的发生,有望成为多种疾病的治疗靶点。本文基于Parthanatos的具体分子机制,从抑制和促进Parthanatos层面对相关疾病治疗策略的研究进展作一综述。Parthanatos is a form of programmed cell death,which is also known as poly(ADP-ribose)polymerase 1(PARP1)-mediated apoptosis-inducing factor(AIF)and macrophage migration inhibitory factor(MIF)-dependent cell death according to its molecular mechanism.Parthanatos is the main cause of a variety of neurodegenerative diseases,such as Parkinson's disease(PD),Alzheimer's disease(AD),motor neuron disease,and is also involved in the pathogenesis of some tumors,such as lung cancer and breast cancer.Therefore,a thorough understanding of the molecular mechanism of Parthanatos is crucial for the therapeutic strategies of related diseases.In recent years,studies have found that effective regulation of the occurrence of Parthanatos by regulating the key proteins PARP1,AIF and MIF is expected to become a therapeutic target for many diseases.Based on the specific molecular mechanism of Parthanatos,this paper reviewed the research progress of therapeutic strategies for related diseases from the aspects of inhibiting and promoting Parthanatos.

关 键 词：Parthanatos 多聚ADP核糖聚合酶1 凋亡诱导因子 巨噬细胞迁移抑制因子 神经退行性疾病 癌症 

分 类 号：Q28[生物学—细胞生物学]