心房颤动致认知功能损害的机制及治疗的研究进展  

Research progress on mechanisms and treatments of cognitive dysfunction in atrial fibrillation

作　　者：郭加欢 陆菁菁[1] 赵性泉 Guo Jiahuan;Lu Jingjing;Zhao Xingquan(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,China National Clinical Research Center for Neurological Diseases,Research Unit of Artificial Intelligence in Cerebrovascular Disease,Chinese Academy of Medical Sciences,Center of Stroke,Beijing Institute of Brain Disorders,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心,北京100070 [2]首都医科大学附属北京天坛医院神经病学中心、国家神经系统疾病临床医学研究中心、中国医学科学院脑血管病人工智能研究创新单元、首都医科大学脑重大疾病研究中心,北京脑重大疾病研究院,脑卒中研究所,北京100070

出　　处：《中华神经科杂志》2023年第12期1428-1434,共7页Chinese Journal of Neurology

基　　金：科技创新2030——“新一代人工智能”重大项目(2022ZD0118005)。

摘　　要：越来越多的证据表明,心房颤动除了会增加死亡率以及卒中风险,还可能增加认知功能障碍及痴呆风险,且独立于卒中事件。然而,目前心房颤动与认知功能的关联在临床对于心房颤动患者的风险分层、监测与治疗管理当中往往被忽视。心房颤动与大脑改变的关系及其机制以及心房颤动相关治疗是否能有效改善脑结构与功能,目前缺乏共识。文中通过检索文献,分析心房颤动与认知功能的关系,探讨其可能的机制,并进一步探讨心房颤动相关治疗对于认知功能和脑部病变的效益。Increasing evidence suggests that atrial fibrillation is associated with an increased risk of cognitive impairment and dementia beyond its association with stroke and mortality.The association is independent of stroke.However,the association between atrial fibrillation and cognitive function has often been overlooked in the management and treatment in clinical practice.There is a lack of consensus on the relationship and its mechanisms between atrial fibrillation and brain dysfunction.Whether treatments targeted atrial fibrillation are effective for brain function remains unknown.Through reviewing relevant literatures,this article analyzed the association between atrial fibrillation and its underlying mechanisms.Furthermore,this article further discussed the effectiveness of atrial fibrillation treatments to cognitive function and brain health.

关 键 词：心房颤动 认知障碍 痴呆 治疗 临床研究性 

分 类 号：R541.75[医药卫生—心血管疾病]