白藜芦醇在多囊卵巢综合征治疗中的研究进展  

Research progress of resveratrol in the treatment of polycystic ovary syndrome

作　　者：张倩杰 高誉 杨菁[1] 李赛姣 Zhang Qianjie;Gao Yu;Yang Jing;Li Saijiao(Reproductive Medicine Center,Renmin Hospital of Wuhan University,Hubei Clinical Research Center for Assisted Ferility and Embryo Development,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院生殖医学中心、湖北省辅助生育与胚胎发育医学临床研究中心,武汉430060

出　　处：《中华生殖与避孕杂志》2023年第11期1178-1182,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金青年基金(81701412);湖北省卫生健康科研基金(WJ2021M158);湖北省自然科学基金(2018CFB491);湖北省联合基金(2022CFD155)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期妇女最常见的生殖内分泌代谢性疾病,主要表现为排卵功能障碍、高雄激素血症、不孕和卵巢多囊样改变,常伴有肥胖、胰岛素抵抗(insulin resistance,IR)和糖耐量异常。近年来,其发病率逐年上升,且尚无完全有效的治疗手段。越来越多的研究显示,白藜芦醇对PCOS具有潜在的治疗价值。本文主要对白藜芦醇改善PCOS的IR及糖脂代谢紊乱、高雄激素血症、炎症与氧化应激的相关研究和机制进展,以及白藜芦醇在PCOS合并不孕症中的应用进行综述。Polycystic ovary syndrome(PCOS)is the most common reproductive endocrine and metabolic disease in women of childbearing age,which is characterized by ovulatory dysfunction,hyperandrogenemia,infertility and polycystic changes of the ovary,often accompanied by obesity,insulin resistance(IR)and impaired glucose tolerance.In recent years,its incidence has increased year by year,and there is no completely effective treatment.More and more studies have shown that resveratrol has potential therapeutic value for PCOS.This article mainly reviews the related research and mechanism progress of resveratrol in improving IR,glucose and lipid metabolism disorders,hyperandrogenism,inflammation and oxidative stress in PCOS,as well as the application of resveratrol in PCOS with infertility.

关 键 词：多囊卵巢综合征 白藜芦醇 胰岛素抵抗 高雄激素血症 

分 类 号：R711.75[医药卫生—妇产科学]