类器官及器官芯片技术在体外胎盘模型构建中的研究进展  

Recent development of organoids and organ-on-a-chip in creation of an in vitro model of the placenta

作　　者：张晓璐 李金枝 王丽 刘颂平 Zhang Xiaolu;Li Jinzhi;Wang Li;Liu Songping(Jinshan Hospital of Fudan University Obstetrics and Gynecology,Shanghai 201508,China;Institutes of Biomedical Sciences Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属金山医院妇产科,上海201508 [2]复旦大学生物医学研究院,上海200032

出　　处：《中华生殖与避孕杂志》2023年第11期1191-1197,共7页Chinese Journal of Reproduction and Contraception

基　　金：上海市卫生健康委员会卫生行业临床研究专项(202140366);复旦大学医工项目(yg2021-025);上海市金山区卫生健康专项科研课题(JSKJ-KTMS-2022-08);复旦大学附属金山医院青年科研启动基金(JYQN-JC-202210、JYQN-JC-202304)。

摘　　要：胎盘具有物质交换及屏障功能,对维持胎儿生长发育至关重要。胎盘功能异常与多种不良妊娠结局有关。现有的体外胎盘模型均存在一定局限性,无法满足研究需要。目前类器官及器官芯片技术发展迅速,在药物研发、基础医学研究等方面展示出了极大的应用前景。构建自真实胎盘的类器官在细胞表型、基因表达等方面均与源组织具有高度一致性。胎盘芯片可体外模拟胎盘屏障,并在药物的胎盘通透性研究中被广泛应用。构建胎盘类器官芯片,或构建包含胎盘、子宫内膜等成分的多器官芯片,对于生殖及围产医学领域的发展具有重要意义。The placenta is the site of material exchange and barrier between mother and the offspring,plays a crucial role in the growth of fetus.Dysfunction of placenta is responsible for varies of adverse pregnancy outcome.Current in vitro experimental models of the placenta all have their limitations and are insufficient for research.Recently,organoid and organ-on-a-chip technology develop rapidly,and provide a potentially powerful approach to drug discovery and basic medical research.Organoids derived from human placenta closely resemble origin trophoblast in cell phenotype,genetic expression and so on.Placenta organ-on-a-chip mimics the placenta barrier and has been used in research of drug transport across the placenta.Establishment of placenta organoid-on-a-chip,or multi-organ chip contains placenta and endometrium cells can be a potential direction of research in the future.

关 键 词：类器官 器官芯片 胎盘屏障 体外模型 

分 类 号：R714[医药卫生—妇产科学] R318.1[医药卫生—临床医学]