2型糖尿病引起的男性生殖功能障碍病因机制的研究进展  

Research progress on etiological mechanism of male reproductive dysfunction caused by type 2 diabetes

作　　者：曾晓亭 胡煜 罗克燕 Zeng Xiaoting;Hu Yu;Luo Keyan(Department of Reproductive Medicine,Department of Obstetrics and Gynecology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院妇产科生殖医学科,遵义563000

出　　处：《中华生殖与避孕杂志》2023年第11期1203-1207,共5页Chinese Journal of Reproduction and Contraception

基　　金：遵义市基金引导专项(遵市科合HZ字(2022)307号、遵市科合HZ字(2022)294号);遵义市学科建设人才专项(遵市科合HZ字(2022)345号);贵州省卫健委科学技术基金项目gzwkj2023-055)。

摘　　要：2型糖尿病(type 2 diabetes,T2D)是一种因胰岛素相对分泌不足或作用障碍导致的代谢性疾病,已成为严重危害人民健康最常见的慢性病之一。我国是糖尿病高发的国家,尤其受高脂高糖饮食的影响,越来越多处于育龄期的男性遭受了此病的困扰。T2D男性患者并发生殖功能障碍会产生性欲减退、阴茎勃起功能障碍、生精障碍、异常射精等。本文就它们的相关机制进行综述,以期为临床上解决此类生殖问题提供借鉴与参考。Type 2 diabetes(T2D),a metabolic disease caused by inadequate insulin secretion or dysfunction,is one of the most common chronic illnesses causing serious health complications in human.The incidence of diabetes in China is high.Increasingly,men in their reproductive years are afflicted with the disease,particularly due to high-fat and high-sugar diets.Male patients with T2D often suffer from reproductive dysfunction,which is characterized by hyposexual desire,penile erectile dysfunction,spermatogenic dysfunction and abnormal ejaculation,etc.In this paper,we review their related mechanisms,in order to provide reference for the clinical solution of these reproductive problems.

关 键 词：2型糖尿病 男性 氧化应激 胰岛素抵抗 生殖功能障碍 

分 类 号：R587.2[医药卫生—内分泌] R698[医药卫生—内科学]