miRNAs在川崎病冠状动脉病变机制中的研究进展  

Advances in miRNAs in the mechanism of coronary artery lesions associated with Kawasaki disease

作　　者：周媛媛(综述) 黄敏(审校)[1] Zhou Yuanyuan;Huang Min(Department of Cardiology,Shanghai Children′s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海交通大学医学院附属儿童医院、上海市儿童医院心内科,200062

出　　处：《国际儿科学杂志》2023年第11期719-723,共5页International Journal of Pediatrics

基　　金：上海市"科技创新行动计划"技术标准项目(21DZ2201400);上海市"科技创新行动计划"医学创新研究专项项目(21Y31900304);上海市卫生健康委员会卫生行业临床研究专项青年项目(20214Y0477)。

摘　　要：川崎病是一种好发于5岁以下儿童的急性发热性疾病, 以中小血管炎为主要病理特征, 最大危害是冠状动脉病变, 可表现为冠状动脉扩张、狭窄、动脉瘤等, 并长期持续进展。miRNAs作为一种短链非编码RNA, 可直接结合mRNA调控转录后水平的基因表达。研究表明, miRNAs在川崎病相关冠状动脉病变的遗传易感性、免疫和炎症反应、血管壁结构与功能异常等方面发挥重要作用。深入探讨表达失调的miRNAs靶点和上下游通路有助于明确冠状动脉病变发生的分子机制, 并为早期诊断、风险预测和靶向治疗提供思路。该文对miRNAs在川崎病冠状动脉病变发生发展过程中的作用机制进行综述。Kawasaki disease is an acute febrile illness that predominantly affects children under 5 years of age.The pathology is distinguished by small and medium-sized vasculitis.The most severe outcome of this disease is the development of coronary artery lesions,which can result in dilation,stenosis,aneurysm,and potentially long-term progression.MiRNAs,a type of short non-coding RNAs,could directly bind to mRNAs to regulate gene expression at the post-transcriptional level.Numerous studies have demonstrated that miRNAs may play an important role in genetic susceptibility,immunity,inflammatory response,and vascular wall structural abnormalities and dysregulation pertaining to Kawasaki disease.Consequently,comprehensive investigations into targets and pathways influenced by dysregulated miRNAs can facilitate the identification of the molecular mechanism underlying coronary artery lesions,thereby provide insights into early diagnosis,risk prediction,and targeted therapeutic intervention.This review succinctly outlines the involvement of miRNAs in the pathogenesis of coronary artery lesions associated with Kawasaki disease.

关 键 词：川崎病 MIRNAS 冠状动脉损伤 血管炎 分子机制 

分 类 号：R725.4[医药卫生—儿科]