氮6-甲基腺苷RNA甲基化修饰调控青春期性发育研究进展  

Advances in the RNA N6-methyladenine modification in regulating pubertal sexual development

作　　者：臧少莲(综述) 尹小琴 李嫔(审校)[1] Zang Shaolian;Yin Xiaoqin;Li Pin(Department of Endocrinology,Shanghai Children′s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海交通大学医学院附属儿童医院上海市儿童医院内分泌科,200062

出　　处：《国际儿科学杂志》2023年第11期750-753,共4页International Journal of Pediatrics

基　　金：国家自然科学基金(81871131, 82201796);上海市自然科学基金(21ZR1453100)。

摘　　要：氮6-甲基腺苷(N6-methyladenine, m6A)甲基化修饰是真核生物RNA中最丰富、最普遍和最保守的内部修饰, 能将不同层次的基因调控相互耦合, 并在表观遗传调控(如RNA剪接、翻译、稳定和异位)中发挥重要作用。研究表明:RNA m6A甲基化修饰是青春期性发育的一个重要因素, 且在性发育过程中RNA m6A甲基化修饰水平随青春期进展而改变。RNA m6A甲基化修饰失调能导致下丘脑促性腺激素释放激素神经元网络功能的紊乱, 而受RNA m6A甲基化修饰所影响的基因可能是调控青春期启动的关键靶点。该文综述了RNA m6A甲基化修饰与青春期性发育之间的研究进展, 为发现治疗疾病的新靶点及改善疾病预后提供依据。N6-methyladenine(m6A)has been identified as the most abundant,common and conserved internal RNA modification.RNA m6A can couple different levels of gene regulation and may play an important role in epigenetic regulation(such as RNA splicing,translation,stabilization,and ectopic).Studies have shown that RNA m6A methylation is an important factor in pubertal sexual development.The abundance of RNA m6A methylation changed with the progression of pubertal development.The abnormalities of RNA m6A methylation can lead to dysfunction of hypothalamic gonadotropin-releasing hormone(GnRH)neuronal networks.Those genes affected by RNA m6A methylation may be critical targets in regulating puberty initiation.The review summarizes the research progress between RNA m6A methylation and pubertal sexual development to provide the evidence to discover new therapeutic targets and improve the prognosis of the disease.

关 键 词：甲基化修饰 青春期性发育 表观遗传 

分 类 号：R725[医药卫生—儿科]