巨噬细胞极化在单纯疱疹病毒1型感染中的作用研究进展  

Research Progress on the Role of Macrophage Polarization in Herpes Simplex Virus Type 1 Infection

作　　者：张豪博 张莹[1] ZHANG Haobo;ZHANG Ying(Yunnan Key Laboratory of Vaccine Research and Development on Severe Infection Diseases,Institute of Medical Biology,Chinese Academy of Medical Science&Peking Union Medical College,Kunming 650118,China)

机构地区：[1]中国医学科学院,北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明650118

出　　处：《病毒学报》2023年第6期1757-1767,共11页Chinese Journal of Virology

基　　金：国家自然科学基金(面上项目)(项目号:82171817),题目:HSV与树突状细胞和天然淋巴细胞的相互作用及其减毒活疫苗研究;云南省应用基础研究计划项目(青年)(项目号:202001AU070142),题目:PD-1改造的单纯疱疹病毒1型在癌症治疗中的应用研究。

摘　　要：巨噬细胞具有功能可塑性,使其能够根据微环境线索不同极化为不同表型,主要分为两种类型,即促炎M1型巨噬细胞和抗炎M2型巨噬细胞,它们在单纯疱疹病毒1型(Herpes simplex virus-1,HSV-1)感染的疾病发展中行使不同的功能。当巨噬细胞出现极化失衡时,可以通过多种因素对其失衡状态进行调节,靶向调节巨噬细胞的极化状态对于治疗HSV-1感染具有重要意义。本文对巨噬细胞极化及其在HSV-1感染中的作用研究进展进行总结,以期为HSV-1感染的进一步研究及治疗提供参考依据。Macrophages possess functional plasticity so that they can be polarized into different phenotypes according to different microenvironmental cues.They are mainly divided into two types:pro-inflammatory M1macrophages and anti-inflammatory M2 macrophages.They show different functions in the development of herpes simplex virus type 1(HSV-1) infected diseases.When macrophage polarization imbalance occurs,it can be regulated by a variety of factors.Targeted regulation of macrophage polarization is of great significance for treatment of HSV-1 infection.This article summarizes the research progress on macrophage polarization and its role in HSV-1 infection,in order to provide reference for further research and treatment of HSV-1 infection.

关 键 词：单纯疱疹病毒1型 巨噬细胞 极化 表型 

分 类 号：R392.1[医药卫生—免疫学]