美白活性成分经皮共输送纳米载体的细胞摄取及功效研究  

Cellular uptake,antioxidant and whitening efficacy of a transdermal co-delivery nanocarrier of glycyrrhiza glabra extract/diglucosyl gallate/elongated seaweed extract

作　　者：张宝江 陈丹 罗丹[2,3] 王曦 李泽巧[1] 赵金枫 洪延涵[2,3] 刘卫 ZHANG Bao-jiang;CHEN Dan;LUO Dan;WANG Xi;LI Ze-qiao;ZHAO Jin-feng;HONG Yan-han;LIU Wei(SGCE Group Co.,Ltd.,Chengdu 61oooo,China;Wuhan Bestcarrier Biotechnology Co.,Ltd.,Wuhan 430075,China;National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan 430075,China;College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]律恩泽雅集团有限公司,四川成都610000 [2]武汉百思凯瑞生物科技有限公司,湖北武汉430075 [3]华中科技大学国家纳米药物工程技术研究中心,湖北武汉430075 [4]华中科技大学生命科学与技术学院,湖北武汉430074

出　　处：《精细与专用化学品》2023年第12期44-49,共6页Fine and Specialty Chemicals

摘　　要：研究光果甘草根提取物/二葡糖基棓酸/伸长海条藻提取物经皮共输送纳米载体(臻耀白)的细胞摄取、抗氧化和美白功效。臻耀白平均粒径为42.2±1.4nm,多分散系数(PDI)为0.189±0.007,Zeta电位为-27.1±0.8mV。臻耀白可显著提高黑素细胞对活性成分的摄取量;可降低活性氧(ROS)水平,抑制B16F10细胞的酪氨酸酶活性和黑素生成;可降低黑素合成相关基因转录水平,从而减少黑素的产生。臻耀白作为新型美白功效原料具有良好的应用前景。The cellular uptake,antioxidant and whitening efficacy of glycyrrhiza glabra extract/diglucosyl gallate/elongated seaweed extract was investigated on a transdermal co-delivery nanocarrier(Zhenyaobai).The average particle size was 42.2±1.4nm,the PDI was 0.189±0.007 and the zeta potential was-27.1±0.8mV.It inhibits the tyrosinase activity and melanin content of B16F10 cells and reduces the level of transcription of genes related to melanin synthesis,thereby reducing melanin production.The study shows that Zhenyaobai has good potential as a newwhitening ingredient.

关 键 词：光果甘草根提取物/二葡糖基棓酸/伸长海条藻提取物 共输送纳米载体 细胞摄取 美白功效 

分 类 号：TQ65[化学工程—精细化工]