药线点灸联合针挑治疗坐骨神经痛的疗效观察及对相关炎症因子的影响  

Observation of medicated thread moxibustion in combination with needle pricking in the treatment of sciatica and its influence on related inflammatory factors

作　　者：王谨莹 张旭清 唐汉庆[1] 李克明[1] 陆青兰 WANG Jinying;ZHANG Xuqing;TANG Hanqing;LI Keming;LU Qinglan(Youjiang Medical University for Nationalities,Baise 533000,China;Baise People’s Hospital,Baise 533000,China)

机构地区：[1]右江民族医学院,百色533000 [2]百色市人民医院,百色533000

出　　处：《上海针灸杂志》2023年第12期1288-1292,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家自然科学基金项目(81960911)。

摘　　要：目的观察药线点灸联合针挑治疗坐骨神经痛的临床疗效及对患者血清相关炎症因子白介素-6(interleukin-6,IL-6)、白介素-1β(interleukin-1β,IL-1β)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平的影响。方法将72例坐骨神经痛患者随机分为对照组和联合组,每组36例。联合组采用药线点灸联合针挑疗法治疗,对照组予口服吲哚美辛片和速效坐骨神经痛丸治疗。观察并比较两组临床疗效、疼痛视觉模拟量表(visual analog scale,VAS)评分、腰椎功能评分以及IL-6、IL-1β和TNF-α水平。比较两组不良反应发生率。结果联合组治愈率高于对照组(P<0.05)。与对照组治疗后比较,联合组治疗后疼痛VAS评分和腰椎功能评分均降低(P<0.05)。联合组治疗后血清IL-6、IL-1β和TNF-α水平低于对照组(P<0.05)。联合组不良反应发生率低于对照组(P<0.05)。结论药线点灸联合针挑治疗可有效缓解坐骨神经痛,疗效优于口服药物治疗,这可能与调节炎症因子IL-6、IL-1β和TNF-α水平相关,且不良反应较少。Objective To observe the clinical efficacy of medicated thread moxibustion combined with needle pricking in the treatment of sciatica and its effect on serum related inflammatory factors interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)levels.Method A total of 72 sciatica patients were randomly divided into a control group and a combination group,with 36 cases in each group.The patients in the combination group were treated with medicated thread moxibustion combined with needle pricking,and the patients in the control group were treated with oral indomethacin tablets and quick-acting sciatica pills.The clinical efficacy,pain visual analog scale(VAS)score,lumbar function score,and levels of IL-6,IL-1βand TNF-αwere observed and compared between the two groups.The incidence of adverse reactions was compared between the two groups.Result The curative rate of the combination group was higher than that of the control group(P<0.05).Compared with the control group after treatment,the pain VAS score and lumbar spine function score were decreased after treatment in the combination group(P<0.05).After treatment,the serum levels of IL-6,IL-1βand TNF-αin the combination group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the combination group was lower than that in the control group(P<0.05).Conclusion Medicated thread moxibustion combined with needle pricking can effectively relieve sciatica,and the curative effect is better than oral medication,which may be related to the regulation of inflammatory factors IL-6,IL-1βand TNF-αlevels,and has fewer adverse reactions.

关 键 词：灸法 药线 针刺疗法 挑治 神经痛 坐骨神经痛 疼痛 炎症因子 

分 类 号：R246.2[医药卫生—针灸推拿学]