小肠固有免疫与糖尿病的研究进展  

Research progress of intestinal innate immunity and diabetes mellitus

作　　者：周琳悦 刘雪辉(指导)[1] 刘燕 贾华楠[1] 马旭红 谢春光[1] ZHOU Linyue;LIU Xuehui;LIU Yan;JIA Huanan;MA Xuhong;XIE Chunguang(School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学临床医学院,成都610075 [2]成都医学院公共教学中心,成都610500

出　　处：《中国免疫学杂志》2023年第12期2638-2645,共8页Chinese Journal of Immunology

基　　金：国家自然科学基金(81904082);四川省科技厅重点研发项目(2019YFS0022)资助。

摘　　要：糖尿病(DM)作为一种常见病与多发病,已在全球范围内成为巨大的慢性疾病负担,其发病机制非常复杂,尚未完全阐明。小肠是体内重要的免疫器官之一,其固有免疫功能与DM的关系已成为医疗领域研究前沿。本文综述小肠固有免疫在DM发病机制中的作用,包括小肠组织屏障功能障碍、小肠固有免疫细胞功能失调与小肠固有免疫分子比例失衡,为相关机制研究提供参考。Diabetes mellitus(DM),as a common and frequently-occurring disease,has become a huge burden of chronic diseases worldwide,whose pathogenesis is very complex and has not yet been fully elucidated.Small intestine is one of important immune organ in body,and relationship between its innate immune function and DM has become forefront of research in medical field.In this paper,role of intestinal innate immunity in pathogenesis of DM is reviewed,including tissue barrier dysfunction of small intestine,dysfunction of intestinal innate immune cells and imbalance of proportion of intestinal innate immune molecules,in order to provide references for future research on related mechanisms.

关 键 词：糖尿病 小肠 固有免疫 

分 类 号：R392.12[医药卫生—免疫学]