原发性干燥综合征炎症发病机制  

Inflammatory pathogenesis of Primary Sjögren's syndrome

作　　者：何思慧 张剑勇(指导) 贾二涛 HE Sihui;ZHANG Jianyong;JIA Ertao(Shenzhen Traditional Chinese Medicine Hospital,Nanjing University of Chinese Medicine,Shenzhen 518033,China)

机构地区：[1]南京中医药大学附属深圳市中医院,深圳518033

出　　处：《中国免疫学杂志》2023年第12期2679-2683,F0003,共6页Chinese Journal of Immunology

基　　金：深圳市“医疗卫生三名工程”项目(SZSM201612080)。

摘　　要：原发性干燥综合征(pSS)是累及多种外分泌腺为主的慢性炎症性自身免疫病,是风湿病科一大类常见的自身免疫病,但是pSS的发病机制仍不明确,以致治疗手段不足。而国际上对于pSS的研究也在日益增多,回顾关于干燥综合征在不同因素下的机制的文献,本文从遗传、环境、自身免疫细胞及自身抗体等因素对干燥综合征的发病机制总结。Primary Sjögren's syndrome(pSS)is a chronic inflammatory autoimmune disease involving a variety of exocrine glands.It is a common autoimmune disease in the department of rheumatology.However,the pathogenesis of pSS is still unclear,re⁃sulting in lack of treatment.While the international research on pSS is also increasing,we review the latest literature on the mecha⁃nism of Sjögren's syndrome under different factors.In this paper,the process mechanism of Sjögren's syndrome is summarized from the aspects of heredity,environment,autoimmune cells and autoantibodies.

关 键 词：干燥综合征 病因 发病机制 

分 类 号：R392[医药卫生—免疫学]