基于因子-聚类分析的1000例男性雄激素性秃发患者中医证候研究  

Study on the traditional Chinese medicine syndromes of 1,000 male patients with androgenetic alopecia based on factor-cluster analysis

作　　者：庄明月 刘青武 田子园 钟施怡 杨顶权[2] ZHUANG Mingyue;LIU Qingwu;TIAN Ziyuan;ZHONG Shiyi;YANG Dingquan(Beijing University of Chinese Medicine,Beijing 100029,China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院

出　　处：《北京中医药大学学报》2023年第11期1574-1581,共8页Journal of Beijing University of Traditional Chinese Medicine

基　　金：首都卫生发展科研专项(No.2016-3-4064)。

摘　　要：目的探究男性雄激素性秃发患者的中医证候分布特点。方法回顾性收集2020年1—12月中日友好医院毛发医学中心收治的1000例男性雄激素性秃发患者的临床资料。采用自行设计的中医症状调查表收集四诊信息,使用Excel软件和SPSS 26.0软件进行描述性频数分析、因子-聚类分析和卡方检验,归纳出主要中医证候及症状分布规律。结果1000例男性雄激素性秃发患者中,按频数统计,排在前5位的症状依次为:头皮出油(94.6%)、头皮脱屑(73.0%)、头皮瘙痒(71.2%)、情志抑郁(67.5%)、倦怠乏力(66.3%)。根据因子-聚类分析得出的4种中医证候依次为湿热内蕴证(34.6%)、肝郁脾虚证(28.7%)、血热风燥证(22.2%)、肝肾亏虚证(14.5%)。20~<30岁患者以湿热内蕴证为主,30~<40岁患者以肝郁脾虚证为主,40~<50岁患者以湿热内蕴证为主。30~<40岁患者的中医证候分布比较差异有统计学意义(P<0.05)。结论男性雄激素性秃发以湿热内蕴证、肝郁脾虚证为主,不同年龄段的证候分布存在差异。因子-聚类分析结果结合临床经验探讨中医证候,对男性雄激素性秃发的临床辨证论治具有参考性。Objective To study the characteristics of traditional Chinese medicine(TCM)syndromes in male patients with androgenetic alopecia(AGA).Methods The clinical data of 1,000 male patients with AGA admitted to the Hair Medicine Center of China-Japan Friendship Hospital from January 2020 to December 2020 were retrospectively collected.A self-designed TCM symptom questionnaire was used to collect clinical information of the four examinations.Descriptive frequency analysis,factor-cluster analysis,and Chi-square test were performed using Excel and SPSS 26.0 software.The clinical data were combined to summarize the main TCM syndromes and symptoms.Results The top five symptoms ranked by frequency were scalp oil(94.6%),scalp scurf(73.0%),scalp pruritus(71.2%),depression(67.5%),and fatigue(66.3%).Four TCM syndromes were derived using factor-cluster analysis:syndrome of internal retention of dampness-heat(34.6%),syndrome of liver depression and spleen deficiency(28.7%),syndrome of blood heat and wind-dryness(22.2%),and syndrome of liver-kidney deficiency(14.5%).Men aged 20 to<30 years were mainly syndrome of internal retention of dampnessheat,those aged 30 to<40 years were mainly syndrome of liver depression and spleen deficiency,and those aged 40 to<50 years were mainly syndrome of internal retention of dampness-heat.There was a significant difference in the distribution of TCM syndromes in patients aged 30 to<40 years(P<0.05).Conclusion Male AGA syndromes are mainly syndrome of internal retention of dampness-heat and syndrome of liver depression and spleen deficiency,and the distribution of syndromes differs across age groups.It is feasible to evaluate TCM syndromes with factor-cluster analysis combined with experts’experiences for the clinical syndrome differentiation and treatment of male AGA.

关 键 词：雄激素性秃发 中医 证候 因子-聚类分析 

分 类 号：R269[医药卫生—中西医结合]