An update on common inherited thrombophilic conditions  

作　　者：Giuseppe Lippi 

机构地区：[1]Section of Clinical Biochemistry,University Hospital of Verona,Verona 37134,Italy

出　　处：《Clinical Research Communications》2023年第4期12-15,共4页临床研究通讯

摘　　要：The term thrombophilia refers to a number of inherited and/or acquired conditions that may be associated with an increased tendency to develop thrombosis.In this sense,hereditary thrombophilia is a genetic disorder of hemostatic proteins that is present at birth and contributes to individuals being at increased risk for venous thrombosis.Three important questions arise from the still ongoing debate about the benefits and limitations of testing for hereditary thrombophilia,which can be summarized as follows:“which tests?”,“when?”,and“how?”.This article attempts to answer these questions by providing an up-to-date overview of the most common and clinically significant inherited thrombophilic disorders(i.e.,antithrombin,protein S and protein C deficiencies,activated protein C resistance,factor V Leiden,and prothrombin gene mutationG20210A),their prevalence,clinical severity,and diagnostic approach,while also highlighting the potential advantages and limitations of testing for inherited thrombophilia.

关 键 词：THROMBOSIS THROMBOPHILIA risk factors testing 

分 类 号：H31[语言文字—英语]