乙型肝炎病毒相关肝癌中表观遗传学的调控机制与应用前景  

Mechanisms and prospects of epigenetics in hepatitis B virus-related hepatocellular carcinoma

作　　者：李善 唐霓[1] Li Shan;Tang Ni(Key Laboratory of Molecular Biology for Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆400016

出　　处：《中华微生物学和免疫学杂志》2023年第11期868-873,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(82072286,82272975);重庆市教委科学技术研究项目(KJZDM202000401)。

摘　　要：乙型肝炎病毒(hepatitis B virus,HBV)感染是肝癌的主要危险因素之一,HBV相关肝癌是全球最常见的肝癌类型。表观遗传学改变在HBV相关肝癌的进展过程中发挥重要作用。本综述主要介绍了HBV相关肝癌的表观遗传学改变,包括异常的DNA甲基化、组蛋白修饰等。同时,本文还阐述了表观遗传学在HBV相关肝癌诊断、治疗和预后评估中的应用,以及对未来研究方向的展望。Hepatitis B virus(HBV)infection is recognized as one of the primary risk factors for hepatocellular carcinoma(HCC),the most frequently diagnosed type of liver cancer worldwide.Epigenetic modifications have been shown to play a pivotal role in the pathogenesis and progression of HBV-related HCC.This review provided an overview of the epigenetic mechanisms underlying HBV-related HCC,including DNA methylation,histone modifications,and others.Furthermore,the potential application of epigenetics in the diagnosis,treatment,and prognosis assessment of HBV-related HCC and some future research directions in this field were discussed in this article.

关 键 词：HBV相关肝癌 表观遗传学 DNA甲基化 组蛋白修饰 

分 类 号：R512.62[医药卫生—内科学] R735.7[医药卫生—临床医学]