传染性软疣治疗药物——Ycanth  

Molluscum contagiosum treatment drug:Ycanth

作　　者：袁媛 郑丽[2] 杜华 何春峰 孙雪林[3] YUAN Yuan;ZHENG Li;DU Hua;HE Chun-feng;SUN Xue-lin(Department of Dermatology,Gansu Provincial Maternity and Child-care Hospital(Gansu Provincial Central Hospital),Lanzhou 730050,China;Department of Pharmacy,China Aerospace Science&Industry Corporation 731 Hospital,Beijing 100074,China;Department of Pharmacy,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)皮肤科,兰州730050 [2]中国航天科工集团七三一医院药剂科,北京100074 [3]北京医院药学部,国家老年医学中心,中国医学科学院老年医学研究院,北京100730

出　　处：《临床药物治疗杂志》2023年第11期37-40,共4页Clinical Medication Journal

基　　金：国家重点研发计划资助项目(2020YFC2009001);2023年度北京医院临床研究“启航”专项(BJ-2023-200)。

摘　　要：传染性软疣因痘病毒科中的传染性软疣病毒感染所致,属于儿童常见的皮肤病毒感染性疾病。斑蝥素治疗软疣历史长达60余年,临床疗效已得到认可。长期以来,斑蝥素存在使用上的局限性,如制剂标准化不足、浓度和治疗持续时间不统一标准、使用繁杂等。2023年7月21日,FDA批准Ycanth(活性成分:斑蝥素)上市,该药为首个用于成人、2岁及以上儿童的软疣局部治疗药物。Ycanth的优点是制造规范、有效浓度恒定和使用便捷,且保持了良好的临床疗效。本文就其药理作用、药动学、临床疗效、安全性、药物相互作用及用法用量等进行综述。Molluscum contagiosum caused by the contagious molluscum contagiosum virus infection in the Poxviridae family,is the most common viral skin infection in children.Cantharidin has a history of over 60 years in treating molluscum contagiosum,and its clinical effectiveness has been recognized.However,cantharidin has long been associated with limitations in its use,such as inadequate standardization of formulations,inconsistent concentrations,varying treatment durations,and complexity in application.On July 21,2023,the U.S.FDA approved Ycanth(active ingredient:cantharidin)for market release.This drug is the first topical treatment for molluscum contagiosum in adults and children aged 2 and above.Ycanth offers advantages in terms of standardized manufacturing,consistent effective concentrations,and ease of use,while maintaining excellent clinical efficacy.This article provides a comprehensive review of its pharmacological action,pharmacokinetics,clinical evaluation,safety,drug interactions,and dosage and administration.

关 键 词：传染性软疣 斑蝥素 临床疗效 安全性 

分 类 号：R986[医药卫生—药品]