阿仑膦酸钠联合阿伐他汀对高脂血症合并骨质疏松患者骨密度、脂代谢及炎症因子的影响  

Effects of alendronate sodium combined with atorvastatin on bone mineral density, lipid metabolism and inflammatory factors in patients with hyperlipidemia complicated with osteoporosis

作　　者：吕海文[1] 张伟锋[1] 梅传林 贾志强 LYU Hai-wen;ZHANG Wei-feng;MEI Chuan-lin;JIA Zhi-qiang(Department of Orthopaedics,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China)

机构地区：[1]河南科技大学第二附属医院骨科一病区,河南洛阳471000

出　　处：《广东医学》2023年第10期1289-1292,共4页Guangdong Medical Journal

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20191247)。

摘　　要：目的 探讨阿仑膦酸钠与阿伐他汀联合治疗下,高脂血症合并骨质疏松患者骨密度、脂代谢及白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平的变化情况。方法 选取2019年7月至2021年12月的65例高脂血症伴骨质疏松患者,随机分为对照组(n=32)和观察组(n=33)。对照组采用单一阿仑膦酸钠片治疗,观察组在阿仑膦酸钠片的基础上与阿伐他汀联合治疗。观察两组临床疗效、骨密度、脂代谢以及IL-6、CRP、TNF-α水平的变化,记录两组患者不良反应发生情况。结果 两组患者治疗前一般资料差异无统计学意义(P>0.05),股骨颈、腰椎L1~4骨密度、总胆固醇(TC)、三酰甘油(TG)以及IL-6、CRP、TNF-α水平比较,差异均无统计学意义(P>0.05)。治疗后观察组与对照组比较,患者股骨颈、腰椎L1~4骨密度升高,TC、TG以及IL-6、CRP、TNF-α水平均显著降低(P<0.05)。观察组总有效率(93.94%)显著高于对照组(75.00%)(χ2=4.477,P=0.034),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 阿仑膦酸钠与阿伐他汀联合治疗高脂血症合并骨质疏松患者,可提高骨密度,改善脂代谢和炎性反应,疗效显著,安全可靠。Objective To investigate changes in bone density,lipid metabolism,and the levels of Interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)in patients with hyperlipidemia complicated by osteoporosis treated with sodium alendronate in combination with atorvastatin.Methods Sixty-five patients with hyperlipidemia and osteoporosis treated at our hospital between July 2019 and December 2021 were randomly divided into a control group(n=32)and an observation group(n=33).The control group received treatment with sodium alendronate alone,while the observation group received combination therapy with atorvastatin on the basis of sodium alendronate treatment.The clinical efficacy,bone density,lipid metabolism,as well as changes in IL-6,CRP,and TNF-αlevels were observed in both groups.Adverse reactions in both groups were also recorded.Results There were no significant differences in general patient data,femoral neck and lumbar spine L1-4 bone density,total cholesterol(TC),triglycerides(TG),and IL-6,CRP,TNF-αlevels between the two groups before treatment(P>0.05).After treatment,compared with the control group,the observation group showed significantly increased bone density in the femoral neck and lumbar spine L1-4,as well as significantly decreased TC,TG,IL-6,CRP,and TNF-αlevels(P<0.05).The total effective rate was significantly higher in the observation group(93.94%)than in the control group(75.00%)(2=4.477,P=0.034),and there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium alendronate in combination with atorvastatin for the treatment of patients with hyperlipidemia complicated by osteoporosis can improve bone density,lipid metabolism,and inflammatory response.The treatment is effective,safe,and reliable.

关 键 词：阿仑膦酸钠 阿伐他汀 高脂血症 骨质疏松 

分 类 号：R452[医药卫生—治疗学] R605[医药卫生—临床医学]