健脾益气汤联合化疗对非小细胞肺癌的治疗效率、生存质量及不良反应影响  

Effect of Jianpi Yiqi Decoction(健脾益气汤) Combined with Chemotherapy on Treatment Efficiency,Quality of Life and Adverse Effects in Non-Small Cell Lung Cancer

作　　者：朱林 孙元鹏 杨军 濮忠建 徐奚如 ZHU Lin;SUN Yuanpeng;YANG Jun;PU Zhongjian;XU Xiru(Hai'an City Hospital of Traditional Chinese Medicine,Hai'an 226600,Jiangsu,China;Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210004,Jiangsu,China)

机构地区：[1]海安市中医院,江苏海安226600 [2]南京中医药大学附属医院,江苏南京210004

出　　处：《实用中医内科杂志》2023年第11期126-129,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：江苏省自然科学基金项目(BK20181235)。

摘　　要：目的 探究健脾益气汤联合化疗对非小细胞肺癌(non-small-ceLl carcinoma,NSCLC)患者的治疗效率、生存治疗及不良反应影响。方法 于2017年6月—2021年6月选取海安市中医院收治的NSCLC晚期患者102例,按数字随机法分为对照组及试验组各51例。对照组行化疗治疗,试验组在其基础上联合健脾益气汤治疗,观察两组患者骨髓抑制、症状积分、不良反应率、生存质量及治疗效率。结果 治疗前,两组患者气短、咳嗽、食欲不振及神疲乏力等症状评定无差异(P>0.05),治疗后,试验组症状评分均低于对照组,且两组患者治疗后均低于治疗前(P<0.05);治疗前,两组Hb、WBC、PLT比较无差异(P>0.05),治疗后,试验组骨髓抑制高于对照组,治疗后患者骨髓抑制均高于治疗前(P<0.05);治疗后,试验组血小板减少、白细胞减少、周围神经毒性、恶心呕吐、腹泻等不良反应发生率均低于对照组(P<0.05);治疗前,两组健康情况、身体功能、心理健康及社会功能等GQOLI-74分值比较无差异(P>0.05),治疗后,试验组GQOLI-74评分高于对照组(P<0.05),治疗后患者GQOLI-74评分高于治疗前(P<0.05);治疗后,试验组患者治疗有效率为96.08%,高于对照组80.39%(P<0.05)。结论 健脾益气汤联合化疗治疗非小细胞肺癌,可提高临床效果,减少化疗带来的毒性,提高患者生存质量,降低不良反应,具有积极意义。Objective To explore the effect of Jianpi Yiqi Decoction(健脾益气汤)combined with chemotherapy on the treatment efficiency,survival treatment and adverse reactions of patients with non-small cell lung cancer(NSCLC).Method From June 2017 to June 2021,102 patients with advanced NSCLC admitted to the Hai'an Hospital of Traditional Chinese Medicine were selected and divided into control group(n=51)and observation group(n=51)according to the digital random method.The control group was treated with chemotherapy,and the observation group was treated with Jianpi Yiqi Decoction on the basis of the control group.The bone marrow suppression,symptom score,adverse reaction rate,quality of life and treatment efficiency of the two groups were observed.Results Before treatment,there was no diference in the evaluation of symptoms such as shortness of breath,cough,loss of appetite and mental fatigue between the two groups(P>0.05),after treatment,the symptom scores of the observation group were lower than those of the control group,and the scores of the two groups after treatment were lower than those before treatment(P<0.05),before treatment,there was no difference in Hb,WBC and PLT between the two groups(P>0.05),after treatment,the bone marrow suppression in the observation group was higher than that in the control group,and the bone marrow suppression after treatment was higher than that before treatment(P<0.05),after treatment,the incidence of adverse reactions such as thrombocytopenia,leukopenia,peripheral neurotoxicity,nausea and vomiting,and diarrhea in the observation group were lower than those in the control group(P<0.05),before treatment,there was no difference in GQOLI-74 scores of health,physical function,mental health and social function between the two groups(P>0.05),after treatment,the GQOLI-74 score of the observation group was higher than that of the control group(P<0.05),and the GQOLI-74 score of the patients after treatment was higher than that before treatment(P<0.05),after treatment,the effective rate of

关 键 词：健脾益气汤 化疗 非小细胞肺癌 治疗效率 生存时间 

分 类 号：R256.1[医药卫生—中医内科学]