益气补肾汤联合免疫抑制剂治疗狼疮性肾炎疗效评价  

Evaluation of Therapeutic Effect of Yiqi Bushen Decoction(益气补肾汤)Combined with Immunosuppressive Agents on Lupus Nephritis

作　　者：戎蓉[1] 连博[1] 范兴刚[1] RONG Rong;LIAN Bo;FAN Xinggang(The Fifth People's Hospital of Fuyang,Fuyang 236037,Anhui,China)

机构地区：[1]阜阳市第五人民医院,安徽阜阳236037

出　　处：《辽宁中医药大学学报》2023年第11期170-173,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：安徽省卫生健康委科研项目(AHWJ2020b173)。

摘　　要：目的探讨益气补肾汤联合免疫抑制剂(注射用环磷酰胺)治疗狼疮性肾炎的疗效。方法予以随机数字表法将2019年1月—2021年6月收治80例狼疮性肾炎患者分为对照组(40例)和治疗组(40例)。两组均给予常规治疗,对照组在此基础上给予注射用环磷酰胺进行治疗,治疗1年;治疗组在对照组基础上给予益气补肾汤进行治疗,治疗3个月,并同对照组随访至1年。比较两组治疗1年后疗效,治疗前、治疗3个月、1年后临床症状改善情况,治疗前、治疗1年后中医证候积分、肾功能相关指标水平及治疗期间不良反应发生情况。结果与对照组比较,治疗组治疗1年后的总有效率较高(92.50%vs 72.50%,P<0.05)。与治疗前比较,治疗3个月、1年后,两组红斑狼疮疾病活动评分(SLEDAI)评分呈逐渐降低趋势,治疗组治疗3个月、1年后的SLEDAI评分低于对照组(P<0.05)。与治疗前比较,治疗1年后,两组面色苍白、乏力倦怠、午后低热、腰膝酸软评分、血清肌酐(SCr)、尿素氮(BUN)、谷丙转氨酶(ALT)及尿24 h尿蛋白定量(24 hUP)水平均降低,治疗组低于对照组(P<0.05);两组血清白蛋白(ALB)水平均升高,治疗组高于对照组(P<0.05)。与对照组比较,治疗组治疗期间的不良反应总发生率较低(5.00%vs 20.00%,P<0.05)。结论益气补肾汤联合注射用环磷酰胺可明显改善狼疮性肾炎患者中医证候及肾功能,进而有助于促进患者临床症状的改善,疗效显著,安全性较高。Objective To investigate the therapeutic effect of Yiqi Bushen Decoction(益气补肾汤)combined with immunosuppressive agents(cyclophosphamide for injection)on lupus nephritis.Methods 80patients with lupus nephritis admitted to our hospital from January 2019 to June 2021 were divided into the control group(40 cases)and the treatment group(40 cases)by random number table method.The two groups were given routine treatment,and the control group was treated with cyclophosphamide for injection on this basis for 1 year;the treatment group was treated with Yiqi Bushen Decoction for 3 months on the basis of the control group,and was followed up to 1 year with the control group.The curative effect after 1year of treatment,the improvement of clinical symptoms before treatment,after 3 months of treatment and after 1 year of treatment,the score of traditional Chinese medicine symptom,level of renal function related indicators before treatment and after 1 year of treatment and the occurrence of adverse reactions during treatment were compared of the two groups.Results Compared with the control group,the total effective rate of the treatment group was higher after 1 year of treatment(92.50%vs 72.50%,P<0.05).Compared with that before treatment,after 3 months and 1 year of treatment,the score of systemic lupus erythematosis disease activity index(SLEDAI)of the two groups showed a gradually decreasing trend,and the score of SLEDAI of the test group after 3 months and 1 year of treatment were lower than those of the control group(P<0.05).Compared with that before treatment,after 1 year of treatment,the scores of pale face,fatigue and tiredness,low fever in the afternoon,waist and knee soreness,serum levels of creatinine(SCr),urea nitrogen(BUN),alanine aminotransferase(ALT)and 24-hour urine protein quantity(24 h UP)of the two groups decreased,and the treatment group was lower than the control group(P<0.05);the level of serum albumin(ALB)of the two groups increased,and the treatment group was higher than that in the control group(

关 键 词：狼疮性肾炎 益气补肾汤 注射用环磷酰胺 中医证候 肾功能 安全性 

分 类 号：R259[医药卫生—中西医结合]