健脾定抽颗粒辅助治疗儿童多发性抽动症脾虚痰聚证的效果观察  

Observation of therapeutic effect of Jianpi Dingchou granules on children with Tourette syndrome of spleen deficiency and phlegm accumulation

作　　者：端木泮泮 李文艳 林丛 Duanmu Panpan;Li Wenyan;Lin Cong(Department of Child Health Care of Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中医院儿童保健科,驻马店463000

出　　处：《中国实用医刊》2023年第20期120-122,F0003,共4页Chinese Journal of Practical Medicine

基　　金：2022年度河南省中医药科学研究专项课题(2022ZY2076)。

摘　　要：目的分析健脾定抽颗粒辅助治疗儿童多发性抽动症脾虚痰聚证的临床效果。方法抽取2019年6月至2022年11月驻马店中医院收治的儿童多发性抽动症脾虚痰聚证患儿60例,按随机数字表法分为对照组(28例)与治疗组(32例)。两组均采用经颅微电流刺激仪作为基础治疗方案,对照组加用盐酸硫必利片,治疗组加用健脾定抽颗粒。比较两组治疗效果;比较两组治疗前后中医证候评分、耶鲁综合抽动症严重程度量表(YGTSS)、神经递质水平(多巴胺、5-羟色胺)、下丘脑-垂体-肾上腺(HPA)轴相关激素水平[皮质醇、肾上腺皮质激素(ACTH)]。结果治疗组总有效率(96.88%,31/32)高于对照组(75.00%,21/28),P<0.05。治疗后,两组张口咧嘴、皱眉眨眼、甩手踢腿评分均较治疗前降低,且治疗组评分低于对照组(P<0.05)。治疗后,两组运动性抽动评分、发声性抽动评分均低于治疗前,且治疗组评分低于对照组(P<0.05)。治疗后,两组多巴胺、5-羟色胺水平均低于治疗前,且治疗组低于对照组(P<0.05)。治疗后,两组皮质醇、ACTH水平均低于治疗组,且治疗组低于对照组(P<0.05)。结论健脾定抽颗粒辅助治疗儿童多发性抽动症脾虚痰聚证的效果显著,可调节神经递质和HPA轴相关激素水平,显著改善临床症状。ObjectiveTo analyze the clinical effect of Jianpi Dingchou granules in the treatment of children with Tourette syndrome of spleen deficiency and phlegm accumulation.MethodsSixty children with Tourette syndrome of spleen deficiency and phlegm accumulation admitted to Zhumadian Traditional Chinese Medicine Hospital from June 2019 to November 2022 were selected,and they were divided into control group(28 cases)and treatment group(32 cases)according to random number table method.Both groups were treated by transcranial micro-current stimulator as the basic treatment scheme.On this basis,the control group was treated with thiapride hydrochloride tablets,and the treatment group was treated with Jianpi Dingchou granules.The treatment efficacy of the two groups were compared.The traditional Chinese medicine syndrome score,Yale global tic severity scale(YGTSS)score,levels of neurotransmitters(dopamine,5-hydroxytryptamine),levels of hypothalamic-pituitary-adrenal(HPA)axis related hormones,including cortisol and adrenocortical hormone(ACTH),of the two groups were compared before and after treatment.ResultsThe total effective rate of the treatment group(96.88%,31/32)was higher than that of the control group(75.00%,21/28),P<0.05.After treatment,the scores of grin,frown and wink,hand and leg kicking in the two groups were lower than those before treatment,and the scores in the treatment group were lower than those in the control group(P<0.05).After treatment,motor tic score and vocal tic score of the two groups were lower than those before treatment,and the scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the levels of dopamine and 5-hydroxytryptamine decreased in both groups,and the levels of them in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of cortisol and ACTH in the two groups decreased,and levels of cortisol and ACTH in the treatment group were lower than those in the control group(P<0.05).ConclusionsJianpi Dingchou gra

关 键 词：多发性抽动症 儿童 脾虚痰聚证 健脾定抽颗粒 

分 类 号：R277.7[医药卫生—中医学]