促性腺激素释放激素(GnRH)类似物在辅助生殖治疗领域中的研究进展  

Research Progress of Gonadotropin-releasing Hormone Analogs in Assisted Reproductive Technology

作　　者：周郁恬 孟艳[1] 刁飞扬[1] 刘金勇[1] Zhou Yutian;Meng Yan;Diao Feiyang;Liu Jinyong(Reproductive Medicine Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210036,China)

机构地区：[1]南京医科大学第一附属医院生殖医学中心,江苏南京210036

出　　处：《南京师大学报（自然科学版）》2023年第4期68-73,共6页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(82271668);江苏省卫生健康委项目(M2020097、YXZXB2016001).

摘　　要：促性腺激素释放激素(GnRH)类似物主要包括GnRH激动剂(gonadotropin-releasing hormone agonist,GnRH-a)和GnRH拮抗剂(gonadotropin-releasing hormone antagonist,GnRH-A),在辅助生殖技术多个治疗环节均发挥着重要作用.近年来,针对不同适宜人群进行的、基于GnRH的控制性卵巢刺激改良策略,在不同适宜人群中的使用显著提高了体外受精成功率.GnRH-a在扳机方案中使用的适宜人群选择及对临床结局的影响已在近年临床研究中有深入探讨.而GnRH-a在黄体支持方案中的使用,适宜人群的选择及使用剂量、时机仍需进一步探索.本文就GnRH类似物在辅助生殖领域中的应用机制及相关临床研究的最新进展进行回顾总结.Gonadotropin-releasing hormone analogs,consisting of gonadotropin-releasing hormone agonist and gonadotropin-releasing hormone antagonist,are involved in multiple links of the process of in vitro fertilization.Continuous exploration of different ovulation promotional protocols has led to the increased pregnancy rate.Recently,the role of GnRH-a in achieving final follicular maturation was intensively investigated.Luteal phase support with GnRH-a improves pregnancy outcomes,while more researches are needed to explore applicable population and the most effective protocol.This paper reviews specific applications of GnRH analogs in assisted reproductive technology to provide reference for clinical treatment.

关 键 词：促性腺激素释放激素类似物 辅助生殖 控制性卵巢刺激方案 扳机方案 黄体支持方案 

分 类 号：R711.6[医药卫生—妇产科学]