心脏死亡器官捐献供肾与亲属活体捐献供肾的移植效果  

A retrospective analysis of the effect of kidney transplantation with donation after cardiac death and living-donor

作　　者：高云浩 邵志强[2] 郭丰富[2] 张振[2] Gao Yunhao;Shao Zhiqing;Guo Fengfu;Zhang Zhen(School of Clinical Medicine,Weifang Medical University,Weifang 261053,Shandong,China;Department of Urology,The People’s Hospital of Linyi,Linyi 276000,Shandong,China.)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261053 [2]临沂市人民医院泌尿外科,山东临沂276000

出　　处：《实用器官移植电子杂志》2023年第6期523-527,共5页Practical Journal of Organ Transplantation(Electronic Version)

基　　金：徐州医科大学附属医院发展基金-面上项目(XYFM202222)。

摘　　要：目的 探讨心脏死亡器官捐献(donation after cardiac death,DCD)供肾与亲属活体捐献(livingdonor,LD)供肾移植术后短期效果的差异,评估DCD供肾移植的可行性及安全性,以便更好地利用DCD来源供肾。方法 选取2017年12月至2023年1月在临沂市人民医院泌尿外科行肾脏移植术后患者,根据供者的来源分为DCD组和LD组。收集两组的临床资料,并比较两组术后不同时间血肌酐变化及术后并发症等发生情况。结果 共纳入患者70例,其中DCD为50例,LD为20例。两组均恢复顺利,术后2周内血肌酐均降至200μmol/L以下,手术时间、住院时间及术后并发症发生率均差异无统计学意义。但DCD组术后2周内血肌酐水平要高于LD组,其中第1~7天及第9天两组血肌酐水平比较差异有统计学意义(P <0.05)。结论 DCD肾移植效果确切,但在术后短期肾功能恢复与LD供肾存在一定的差异,需要加强术前评估。Objective To analyze the recovery of renal function after kidney transplantation from different donors,to explore the difference of short-term effect between donation after cardiac death(DCD) and living-donor(LD),and to evaluate the feasibility and safety of DCD kidney transplantation and make better use of DCD donor.Methods Participants who underwent kidney transplantation in Organ Transplantation Center,the Department of Urology,Linyi people's Hospital from December 2017 to January 2023 were selected.According to the source of donors,they were divided into DCD group and LD group.Then the demographic distribution between the two groups was analyzed,and the serum creatinine(Scr) and postoperative complications of the two groups at different time were compared.Results A total number of 70 patients were enrolled,including 50 patients with DCD and 20 patients with LD.Within two weeks after operation,the Scr level decreased to below 200 μmol/L,but the Scr level in DCD group was higher than LD group on day 1 ~ 7and 9 after operation,the difference was statistically significant(P < 0.05).Conclusion The effect of DCD renal transplantation is accurate,but there is a certain difference between the short-term renal function recovery after operation compared with LD donor kidney,therefore,preoperative evaluation should be strengthened.

关 键 词：终末期肾病 肾移植 心脏死亡器官捐献 亲属活体捐献 移植效果 

分 类 号：R699.2[医药卫生—泌尿科学]